Synthesis of hydroxyapatite nanotubes for biomedical applications

Chandanshive, Balasaheb; Rai, Priyanka; Rossi, André L.; Ersen, Ovidiu; Khushalani, Deepa

doi:10.1016/j.msec.2013.03.022

Cited by 43 publications

(27 citation statements)

References 26 publications

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“…These properties have made HA widely used in biomedical applications. Therefore, many methods have been employed to synthesize this bioceramic, such as combustion preparation, electrochemical deposition, hydrolysis, precipitation, sputtering, multiple emulsion, solid-state reaction, biomimetic deposition, solvothermal method, sol-gel, and hydrothermal process [11][12][13][14][15][16][17][18][19][20][21][22][23], which have led to diverse morphologies such as ribbons, rods, wires, and tubes [24][25][26][27][28][29]. However, to eliminate mechanical weaknesses, researchers have used different reinforcing materials.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Graphene Nanoribbons–Hydroxyapatite Nanocomposite Applicable in Biomedicine and Theranostics

Nosrati

Sarraf-Mamoory

Ahmadi

et al. 2020

JNT

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In order to investigate the effect of graphene nanoribbons on the final properties of hydroxyapatite-based nanocomposites, a solvothermal method was used at 180 °C and 5 h for the synthesis of graphene nanoribbons–hydroxyapatite nanopowders by employing hydrogen gas injection. Calcium nitrate tetrahydrate and diammonium hydrogenphosphate were used as calcium and phosphate precursors, respectively. To synthesize the powders, a solvent containing diethylene glycol, anhydrous ethanol, dimethylformamide, and water was used. Graphene oxide nanoribbons were synthesized by chemical unzipping of carbon nanotubes under oxidative conditions. The synthesized powders were consolidated by spark plasma sintering methodat 950 °C and a pressure of 50 MPa. The powders and sintered samples were then evaluated using X-ray diffraction, Raman spectroscopy, high-resolution transmission electron microscopy, Vickers microindentation techniques, and biocompatibility assay. The findings of this study showed that the final powders synthesized by the solvothermal method had calcium to phosphate ratio of about 1.67. By adding a small amount of graphene nanoribbon (0.5%W), elastic modulus and hardness of hydroxyapatite increased dramatically. In biological experiments, the difference of hydroxyapatite effect in comparison with the nanocomposite was not significant. The findings of this study showed that graphene nanoribbons have a positive effect on the properties of hydroxyapatite, and these findings would be useful for the medical and theranostic application of this type of nanocomposites.

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Section: Introductionmentioning

confidence: 99%

Synthesis of Graphene Nanoribbons–Hydroxyapatite Nanocomposite Applicable in Biomedicine and Theranostics

Nosrati

Sarraf-Mamoory

Ahmadi

et al. 2020

JNT

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“…In the case of Wang et al [474] AAO membranes were used to produce PLGA porous membranes but not incorporated into the scaffold whereas in Poinern et al [481], pHEMA was coated onto AAO membranes as-is and also demonstrated strong biocompatibility with cellular adhesion. Hydroxyapatite scaffolds for regeneration and growth of bone can be produced from AAO templates as well [482]. In other instances, commercial, porous polymeric foams and sponges such as polyurethane [483,484] can be used to generate porous frameworks for hydroxyapatite precipitation and growth.…”

Section: Scaffolds and Membranesmentioning

confidence: 99%

Template-based syntheses for shape controlled nanostructures

Pérez-Page

et al. 2016

Advances in Colloid and Interface Science

129

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A variety of nanostructured materials are produced through template-based synthesis methods, including zerodimensional, one-dimensional, and two-dimensional structures. These span different forms such as nanoparticles, nanowires, nanotubes, nanoflakes, and nanosheets. Many physical characteristics of these materials such as the shape and size can be finely controlled through template selection and as a result, their properties as well. Reviewed here are several examples of these nanomaterials, with emphasis specifically on the templates and synthesis routes used to produce the final nanostructures. In the first section, the templates have been discussed while in the second section, their corresponding synthesis methods have been briefly reviewed, and lastly in the third section, applications of the materials themselves are highlighted. Some examples of the templates frequently encountered are organic structure directing agents, surfactants, polymers, carbon frameworks, colloidal sol-gels, inorganic frameworks, and nanoporous membranes. Synthesis methods that adopt these templates include emulsion-based routes and template-filling approaches, such as self-assembly, electrodeposition, electroless deposition, vapor deposition, and other methods including layer-by-layer and lithography. Templatebased synthesized nanomaterials are frequently encountered in select fields such as solar energy, thermoelectric materials, catalysis, biomedical applications, and magnetowetting of surfaces.

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“…Osteoconductivity of the material containing such nanostructures is directly dependent on their specific surface area [11], which also favors the high loading capacity with respect to various biologically active substances, given that adsorption presents the sole mechanism of drug loading when it comes to HA. One-dimensional HA nano- and micro-structures for potential biomedical applications, such as tubes [12,13], wires [14], rods [15–17], ribbons [18] and similar, morphological porous and hierarchically assembled 3D varieties, are especially good candidates to fulfill these two demands. The combined effects of nano- and micro-sized surfaces in 1D HA materials could not only be optimal for cell proliferation and osteogenic differentiation, but also beneficial for the expression of angiogenetic factors in stem cell differentiation [19].…”

Section: Introductionmentioning

confidence: 99%

Hydrothermally processed 1D hydroxyapatite: Mechanism of formation and biocompatibility studies

Stojanović

Ignjatović

et al. 2016

Materials Science and Engineering: C

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Recent developments in bone tissue engineering have led to an increased interest in one-dimensional (1D) hydroxyapatite (HA) nano- and micro-structures such as wires, ribbons and tubes. They have been proposed for use as cell substrates, reinforcing phases in composites and carriers for biologically active substances. Here we demonstrate the synthesis of 1D HA structures using an optimized, urea-assisted, high-yield hydrothermal batch process. The one-pot process, yielding HA structures composed of bundles of ribbons and wires, was typified by the simultaneous occurrence of a multitude of intermediate reactions, failing to meet the uniformity criteria over particle morphology and size. To overcome these issues, the preparation procedure was divided to two stages: dicalcium phosphate platelets synthesized in the first step were used as a precursor for the synthesis of 1D HA in the second stage. Despite the elongated particle morphologies, both the precursor and the final product exhibited excellent biocompatibility and caused no reduction of viability when tested against osteoblastic MC3T3-E1 cells in 2D culture up to the concentration of 2.6 mg/cm2. X-ray powder diffraction combined with a range of electron microscopies and laser diffraction analyses was used to elucidate the formation mechanism and the microstructure of the final particles. The two-step synthesis involved a more direct transformation of DCP to 1D HA with the average diameter of 37 nm and the aspect ratio exceeding 100:1. The comparison of crystalline domain sizes along different crystallographic directions showed no signs of significant anisotropy, while indicating that individual nanowires are ordered in bundles in the b crystallographic direction of the P63/m space group of HA. Intermediate processes, e.g., dehydration of dicalcium phosphate, are critical for the formation of 1D HA alongside other key aspects of this phase transformation, it must be investigated in more detail in the continuous design of smart HA micro- and nano-structures with advanced therapeutic potentials.

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Synthesis of hydroxyapatite nanotubes for biomedical applications

Cited by 43 publications

References 26 publications

Synthesis of Graphene Nanoribbons–Hydroxyapatite Nanocomposite Applicable in Biomedicine and Theranostics

Synthesis of Graphene Nanoribbons–Hydroxyapatite Nanocomposite Applicable in Biomedicine and Theranostics

Template-based syntheses for shape controlled nanostructures

Hydrothermally processed 1D hydroxyapatite: Mechanism of formation and biocompatibility studies

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