Synthesis of hydrogels based on poly(NIPAM) inserted into collagen sponge

A novel thermo-responsive hydrogel based on salecan and poly(N-isopropylacrylamide): Synthesis and characterization

“…Two factors, the hydrophilic property and polymer density, might account for this consequence. Chiriac et al [18] reported that the swelling ratio could be enhanced by increasing the content of hydrophilic compounds for a larger affinity to water. In this work, salecan is a water-soluble polysaccharide and successfully interpenetrated into the PNIPAm network as descripted above.…”

Hybrid collagen-based hydrogels with embedded montmorillonite nanoparticles

“…The hydrogel synthesis is described in a previous study [17]. Briefly, the hydrogels based on three-dimensional collagen matrix, N-isopropylacrylamide and diethylene glycol diacrylate in various weight ratios - Table 1 -were synthesized through a radicalic process.…”

“…In our previous studies, semi-interpenetrate polymeric networks based on collagen and poly(N-isopropylamide) with decreased rate of biodegradability comparative with pure collagen and improved properties have been designed, regarding swelling capacity, thermal stability [17,18]. The effect of inorganic nanoparticles on hybrid hydrogel properties, as well as their biocompatibility with living cells and the immune response parameters followed by evaluation of chronic inflammation in rats, is presented in literature [19].…”

“…The present study is focused on the development and characterization of novel hybrid collagen/N-isopropylamide hydrogels with embedded inorganic nanoparticles targeted for tissue engineering applications, as scaffolds to cover the burned tissues with a design to support the healing and regeneration process of the damaged skin layers. With collagen as a major structural protein in the human body, the poly(N-isopropylacrylamide) attend to form a biomaterial with sensitivity to temperature [17,18], nearest the human body temperature, which enables the preparation of polymeric scaffolds as carriers for therapeutic agents essential in tissue engineering, as well as to release bioactive compounds in a controlled manner by its sensitivity to environmental stimuli. The structural, morphological and rheological characterizations are disputed along with the adhesion capacity of hybrid hydrogels, emphasizing the composition and nanoclay type influence.…”

Bioactive core material for porous load-bearing implants

“…The bioglassy scaffold are not very developed. In [81] the macroporous bioactive scaffold was produced with a use of crosslinked gelatin nanocomposite and bioactive glass nanoparticles. The resulting nanocomposite had pores ranged between 0 and 250 nm and a porosity of 72-86%, with chemical bonds between the nanoparticles of bioglass and gelatin.…”