Synthesis of High‐Molecular Weight Polymers Based on <i>N,N</i>‐Diallyl‐<i>N</i>‐Methylamine

Timofeeva, L. M.; Vasilieva, Yuliya A.; Klescheva, Natalia A.; Gromova, G. L.; Тимофеева, Г. И.; Ребров, А. В.; Topchiev, D. A.

doi:10.1002/macp.200290015

Cited by 17 publications

(3 citation statements)

References 19 publications

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“…Последний повторно инициирует новую растущую цепь (г) (4), и таким образом имеет место основное равновесие (5). RAFT-агент способен также вступать в реакцию с радикалом роста (a) (6), образуя таким образом полимер (з) с CH 2 =CH-и тиокарбонильной группами на противоположных концах макромолекулярной цепи.…”

Section: рис 1 циклополимеризация даатфа (инициатор -44-азобис-(4цианопентановая кислота) ) при эффективной передаче цепи на мономер в прunclassified

“…Второй метод, использованный в работе -диффузионно-седиментационный анализ, являющийся гидродинамическим методом для определения молекулярной массы [10]. Образцы ПДААТФА исследовали в 1 М NaCl при 298 К. Растворитель с высоким значением ионной силы был использован с целью устранения влияния полиэлектролитного эффекта в растворах диаллиламмониевых полимеров [4][5][6][7].…”

“…Это обусловлено необходимостью исследования зависимости свойств полимеров от их молекулярно-массового распределения. В случае полимеров диаллильного ряда, в частности, протонированных полимеров диаллиламмониевого ряда, имеет место деградационная передача цепи на мономер, которая отрицательно влияет на ширину молекулярно-массового распределения [4][5][6].…”

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Синтез Протонированных Полимеров Диаллиламмониевого Ряда С Узким Молекулярно-Массовым Распределением Методом Raft-Полимеризации

Еременко¹,

Симонова²

2021

Синтез Протонированных Полимеров Диаллиламмониевого Ряда С Узким Молекулярно-Массовым Распределением Методом Raft-Полимеризации

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The present work investigates the applicability of the RAFT polymerization method for the polymerization of protonated diallylammonium monomers that proceeds with an efficient chain transfer to the monomer. It has been shown that in the course of radical polymerization of diallylammonium trifluoroacetate in the presence of a radical initiator and xanthate as a RAFT agent, polydiallylammonium trifluoroacetate with a narrow molecular weight distribution (MWD) is obtained. The structure of the polymer was confirmed by 1 H NMR and FTIR spectroscopy. Molecular weight and MWD were determined by light scattering, diffusion sedimentation analysis, and analytical sedimentation.

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Синтез Протонированных Полимеров Диаллиламмониевого Ряда С Узким Молекулярно-Массовым Распределением Методом Raft-Полимеризации

Еременко¹,

Симонова²

2021

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Antimicrobial polymers: mechanism of action, factors of activity, and applications

Timofeeva

Kleshcheva

2010

Appl Microbiol Biotechnol

531

447

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Complex epidemiological situation, nosocomial infections, microbial contamination, and infection risks in hospital and dental equipment have led to an ever-growing need for prevention of microbial infection in these various areas. Macromolecular systems, due to their properties, allow one to efficiently use them in various fields, including the creation of polymers with the antimicrobial activity. In the past decade, the intensive development of a large class of antimicrobial macromolecular systems, polymers, and copolymers, either quaternized or functionalized with bioactive groups, has been continued, and they have been successfully used as biocides. Various permanent microbicidal surfaces with non-leaching polymer antimicrobial coatings have been designed. Along with these trends, new moderately hydrophobic polymer structures have been synthesized and studied, which contain protonated primary or secondary/tertiary amine groups that exhibited rather high antimicrobial activity, often unlike their quaternary analogues. This mini-review briefly highlights and summarizes the results of studies during the past decade and especially in recent years, which concern the mechanism of action of different antimicrobial polymers and non-leaching microbicidal surfaces, and factors influencing their activity and toxicity, as well as major applications of antimicrobial polymers.

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Nonquaternary poly(diallylammonium) polymers with different amine structure and their biocidal effect on Mycobacterium tuberculosis and Mycobacterium smegmatis

Timofeeva

Kleshcheva

Shleeva

et al. 2015

Appl Microbiol Biotechnol

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Mycobacteria, especially Mycobacterium tuberculosis, are one of the most dangerous types of microorganisms to cause diseases and mortality. Due to the known distinctive structure of their cell wall, mycobacteria are resistant to majority of antibiotics and common chemical disinfectants, including quaternized low molecular weight and polymer biocides. In this work, nonquaternary protonated polydiallylamines (PDAAs) based on protonated monomers of the diallylamine (DAA) series have been synthesized, secondary s-PDAA and tertiary t-Me-PDAA and t-Et-PDAA (with Me and Et N-substituents). The antimicrobial actions of PDAAs on M. tuberculosis and Mycobacterium smegmatis have been studied, namely, dependences of the activity on the amine structure, length of alkyl N-substituents, M w of polymers, treatment time, and cell concentration. All PDAAs examined at different conditions have been found to exhibit strong bactericidal effect on M. smegmatis and M. tuberculosis, including "nonculturable" dormant M. tuberculosis cells. The quaternary counterpart poly(diallyldimethylammonium chloride) (PDADMAC) and current antibiotics rifampicin and ciprofloxacin have been also tested and shown to be significantly less efficient or inactive at all (at the maximum tested concentration of 500 μg mL(-1)). s-PDAA appeared to be the most effective or exhibited similar activity to t-Me-PDAA, while t-Et-PDAA appeared to be less active, especially against M. tuberculosis. The results obtained indicate a key role of the nonquaternary ammonium groups in the mycobactericidal action of PDAAs. Examination under an optical microscope in the epifluorescence mode has evidenced damage of the inner membrane permeability of M. smegmatis cells under the impact of PDAAs after 20 min. Studies on electrophoretic mobility (zeta-potential) of M. smegmatis cells and some model liposomes in the presence of PDAAs have revealed a small negative charge of mycobacteria outer surface and recharge in the presence of PDAAs. A conclusion was made that bactericidal activity of PDAAs is related to the disturbance of the integrity of the mycobacterial cell wall followed by damage of the inner membrane permeability.

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Synthesis of High‐Molecular Weight Polymers Based on N,N‐Diallyl‐N‐Methylamine

Cited by 17 publications

References 19 publications

Синтез Протонированных Полимеров Диаллиламмониевого Ряда С Узким Молекулярно-Массовым Распределением Методом Raft-Полимеризации

Синтез Протонированных Полимеров Диаллиламмониевого Ряда С Узким Молекулярно-Массовым Распределением Методом Raft-Полимеризации

Antimicrobial polymers: mechanism of action, factors of activity, and applications

Nonquaternary poly(diallylammonium) polymers with different amine structure and their biocidal effect on Mycobacterium tuberculosis and Mycobacterium smegmatis

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