Synthesis of hemocompatible materials based on branched polyvinyl alcohol

Семенова, М. В.; Osadchenko, S. V.; Mezhuev, Ya. O.; Shtilman, Mikhail I.; Semenova, Irina Nikolaevna

doi:10.1134/s1070427216080115

Cited by 10 publications

(1 citation statement)

References 7 publications

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“…Therefore, the activation of platelets or attachment of red blood cells would not be triggered upon contact with PVA. 28,29 Wound healing assay showed that AGE-loaded scaffolds showed significantly higher wound healing activity than other groups, as evidenced by histopathological examinations and wound closure studies. This higher healing activity could be due to the following reasons.…”

Section: Discussionmentioning

confidence: 97%

Wound healing and anti-inflammatory effects of Anethum graveolens extract loaded in PVA fibers: An in vitro and in vivo study

Wang²

2022

Journal of Bioactive and Compatible Polymers

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Anethum graveolens extract (AGE) is known for its anti-inflammatory, antioxidative, and antibacterial activities. As wound infection, hyperactivity of inflammatory responses, and high oxidative stress are the leading causes of delayed wound healing, we were encouraged to design a delivery vehicle for AGE to develop a potential wound dressing material. In the current study, AGE was incorporated into the polyvinyl alcohol (PVA) scaffolds matrix via the electrospinning method. Various characterization methods were applied to assess the physicochemical and biological properties of the dressings. Cell culture studies with fibroblast cell line showed that AGE-loaded dressings could significantly promote cell viability under normal and oxidative stress conditions. The prepared wound dressings’ wound healing and anti-inflammatory properties were investigated on an excisional injury rat model. Wound healing assay showed that AGE-delivering wound dressings could significantly improve the wound healing response, as evidenced by a significantly higher rate of wound closure, epithelial thickness, and collagen deposition. Gene expression analysis revealed that the produced dressings downregulated inflammation-associated genes such as IL-1β and NFK-β. This preliminary research suggests the potential applicability of AGE-loaded PVA dressings in the clinic.

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Section: Discussionmentioning

confidence: 97%