Strategies to improve the hemocompatibility of biodegradable biomaterials

Mulinti, Pranothi; Brooks, Jeff; Lervick, B.; Pullan, Jessica E.; Brooks, Amanda E.

doi:10.1016/b978-0-08-100497-5.00017-3

Cited by 34 publications

(32 citation statements)

References 122 publications

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“…Poly(lactic-co-glycolic) acid (PLGA) is a block copolymer of PGA and PLA which has been considered as one of the most potent candidates for biomedical applications. 118,119 PLGA has been extensively used to fabricate tissue engineering scaffolds due to its biocompatibility, adjustable degradation rate, nontoxicity, solubility in organic solvents and tunable mechanical properties. 98 Moreover, PLGA has been extensively applied for cardiac tissue engineering applications.…”

Section: Poly(lactic-co-glycolic Acid)mentioning

confidence: 99%

<p>Biodegradable Nanopolymers in Cardiac Tissue Engineering: From Concept Towards Nanomedicine</p>

Nasr¹,

Rabiee²,

Hajebi³

et al. 2020

IJN

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Cardiovascular diseases are the number one cause of heart failure and death in the world, and the transplantation of the heart is an effective and viable choice for treatment despite presenting many disadvantages (most notably, transplant heart availability). To overcome this problem, cardiac tissue engineering is considered a promising approach by using implantable artificial blood vessels, injectable gels, and cardiac patches (to name a few) made from biodegradable polymers. Biodegradable polymers are classified into two main categories: natural and synthetic polymers. Natural biodegradable polymers have some distinct advantages such as biodegradability, abundant availability, and renewability but have some significant drawbacks such as rapid degradation, insufficient electrical conductivity, immunological reaction, and poor mechanical properties for cardiac tissue engineering. Synthetic biodegradable polymers have some advantages such as strong mechanical properties, controlled structure, great processing flexibility, and usually no immunological concerns; however, they have some drawbacks such as a lack of cell attachment and possible low biocompatibility. Some applications have combined the best of both and exciting new natural/ synthetic composites have been utilized. Recently, the use of nanostructured polymers and polymer nanocomposites has revolutionized the field of cardiac tissue engineering due to their enhanced mechanical, electrical, and surface properties promoting tissue growth. In this review, recent research on the use of biodegradable natural/synthetic nanocomposite polymers in cardiac tissue engineering is presented with forward looking thoughts provided for what is needed for the field to mature.

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Section: Poly(lactic-co-glycolic Acid)mentioning

confidence: 99%

<p>Biodegradable Nanopolymers in Cardiac Tissue Engineering: From Concept Towards Nanomedicine</p>

Nasr¹,

Rabiee²,

Hajebi³

et al. 2020

IJN

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show abstract

“…It can be transformed from the α-helix to the β-sheet by the silkworm. With the presence of β-sheet structure, SF fiber has excellent mechanical properties and good biocompatibility, oxygen permeability and biodegradability, and so on [106][107][108]. SF can be processed into fibers, membrane, hydrogel, or gel spongy body, which can be applied in the external wound care, anticoagulant, sustained drug release, tissue framework material, and other fields [108].…”

Section: Research On the Electrospinning Of Silk Fibroinmentioning

confidence: 99%

Advances in Electrospinning of Natural Biomaterials for Wound Dressing

Fa-dong

Jia

et al. 2020

Journal of Nanomaterials

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Electrospinning has been recognized as an efficient technique for the fabrication of polymer nanofibers. Various polymers have been successfully electrospun into ultrafine fibers in recent years. These electrospun biopolymer nanofibers have potential applications for wound dressing based upon their unique properties. In this paper, a comprehensive review is presented on the researches and developments related to electrospun biopolymer nanofibers including processing, structure and property, characterization, and applications. Information of those polymers together with their processing condition for electrospinning of ultrafine fibers has been summarized in the paper. The application of electrospun natural biopolymer fibers in wound dressings was specifically discussed. Other issues regarding the technology limitations, research challenges, and future trends are also discussed.

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“…In both cases, their structures present several aliphatic ester linkages susceptible to hydrolysis, not depending on the action of enzymes to undergo biodegradation and, therefore, precluding inflammatory responses [ 7 ]. Thus, the products of hydrolytic degradation can either be metabolized, through the inclusion in a cell’s metabolic pathway, or eliminated by renal secretion [ 11 ]. In both cases, physical–mechanical properties and biodegradation behavior can be tailored by blending, copolymerization or by changing the macromolecular architecture [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Photocurable Polymeric Blends for Surgical Application

et al. 2020

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The preparation of photocrosslinkable bioadhesives synthesized from oligomers of lactic acid and polycaprolactone (PCL), both functionalized with 2-isocyanoethyl acrylate (AOI), were studied. The obtained modified macromers of LA-AOI (mLA) and PCL-AOI (mCL) were chemically characterized by 1H NMR and used to formulate polymeric blends with different mass proportions, 1:1, 1:2 and 2:1, respectively. Subsequently, the produced blends were crosslinked, considering two UV irradiation times: 30 and 120 s. After their production, the thermal and mechanical properties of bioadhesives were assessed, where upon the rheology, gel content, hydrolytic degradation and dynamic contact angles were determined. Furthermore, the cytotoxic profile of bioadhesives was evaluated in contact with human dermal fibroblasts cells, whereas their antibacterial effect was studied monitoring Escherichia coli and S. aureus growth. Overall, flexible and resistant films were obtained, presenting promising features to be used as surgical bioadhesives.

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Strategies to improve the hemocompatibility of biodegradable biomaterials

Cited by 34 publications

References 122 publications

<p>Biodegradable Nanopolymers in Cardiac Tissue Engineering: From Concept Towards Nanomedicine</p>

<p>Biodegradable Nanopolymers in Cardiac Tissue Engineering: From Concept Towards Nanomedicine</p>

Advances in Electrospinning of Natural Biomaterials for Wound Dressing

Photocurable Polymeric Blends for Surgical Application

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