Synthesis of Green Copper Nanoparticles Using Medicinal Plant Krameria sp. Root Extract and Its Applications

Abstract

Nanotechnology is one of the most dynamic research areas and the fastest-growing market. Developing eco-friendly products using available resources to acquire maximum production, better yield, and stability is a great challenge for nanotechnology. In this study, copper nanoparticles (CuNP) were synthesized via the green method using root extract of the medical plant Rhatany (Krameria sp.) as a reducing and capping agent and used to investigate the influence of microorganisms. The maximum production of CuNP was noted at 70 °C after 3 h of reaction time. The formation of nanoparticles was confirmed through UV-spectrophotometer, and the product showed an absorbance peak in the 422–430 nm range. The functional groups were observed using the FTIR technique, such as isocyanic acid attached to stabilize the nanoparticles. The spherical nature and average crystal sizes of the particle (6.16 nm) were determined using Transmission Electron Microscopy (TEM), Scanning Electron Microscopy (SEM), and X-ray diffractometer (XRD) analysis. In tests with a few drug-resistant pathogenic bacteria and fungus species, CuNP showed encouraging antimicrobial efficacy. CuNP had a significant antioxidant capacity of 83.81% at 200 g/m−1. Green synthesized CuNP are cost-effective and nontoxic and can be applied in agriculture, biomedical, and other fields.

Biosynthesis of Copper Nanoparticles with Medicinal Plants Extracts: From Extraction Methods to Applications

“…These reports correspond to NPs synthesized from the plant extracts of Krameria sp. in conjugation with (CuSO 4 )•5H 2 O, exhibiting a diameter of 6 nm without apparent aggregation [104]. A similar case was found in NPs obtained with extracts of Galeopsis herba and Carum carvi in conjugation with the same precursor salt Cu(NO 3 )2 •3H 2 O, where the synthesized NPs had a diameter of 5-10 and 12 nm, respectively [90,105].…”

“…One of the most important advantages of CuNPs obtained by green synthesis is that their precursors make them non-toxic for humans, affordable, and easily optimized [87]. Because of their capacity to interact with biological systems, these NPs can be used as antioxidants, anticancer, and antimicrobial agents [87,104,121].…”

Nanoformulations in Pharmaceutical and Biomedical Applications: Green Perspectives

“…The impact of nanomaterials on ecosystems and their potential to accumulate in the environment are areas of ongoing research [ 379 , 380 ]. There are ethical considerations regarding the use of nanopharmaceuticals, especially with regard to potential unknown risks and long-term effects [ 381 , 382 ]. Public perception and acceptance of nanotechnology in medicine may influence the adoption of nanopharmaceuticals.…”

Biological Synthesis of Copper Nanoparticles Using Edible Plant Allium monanthum: Characterization of Antibacterial, Antioxidant, and Anti-Inflammatory Properties Using In Silico Molecular Docking Analysis

“…Recently, CuNPs have been spotlighted as critical components in future nanodevices and sensors due to their high catalytic activity, chemical stability, antimicrobial properties, electrical conductivity and biocompatibility [8,9]. CuNPs are promising nanomaterials that can be used in various biomedical and pharmaceutical applications, such as for antimicrobials, antivirals, wound healing, food packaging, water disinfection, surgical instrument manufacturing and pathogen detection assays [10]. CuNPs commonly have good antibacterial properties since they easily undergo oxidation and tend to dissolve in ionic aqueous media.…”

“…To date, different natural resources have been utilized for the green synthesis method: for example, plants, algae, bacteria, fungi, food waste, and so on. Plants and their active ingredients can provide a suitable medium for the largescale production of various metallic NPs, and it becomes a novel and environmentally friendly process [7][8][9][10][11][12][13][14]. Plant-mediated NP synthesis has many advantages, such as ease of use, biological safety, the variety of active metabolites in the synthesis reaction, lower preparation time, and production of high-purity NPs.…”