Synthesis of gold nanoflowers using deep eutectic solvent with high surface enhanced Raman scattering properties

Mahyari, Farzaneh Aghakhani; Tohidi, Maryam; Safavi, Afsaneh

doi:10.1088/2053-1591/3/9/095006

Cited by 23 publications

(21 citation statements)

References 55 publications

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“…Nanorods, nanostars, nanoflowers have already been investigated in order to obtain reproducible SERS spectra of biological molecules with better enhancement in a cell-free environment [131,132,133,134]. For example, gold nanostars and nanoflowers provide better enhancement than spheres since the rough surface provides better electromagnetic enhancement and also provides a large surface area for the molecule adsorption [135,136]. In another study, the comparison of rhodamine-6G (R6G) SERS spectra obtained with star, triangle and sphere shaped AuNPs showed that the characteristic Raman bands of R6G at 613, 775, 1130, 1278, 1364, 1389, 1512, and 1651 cm −1 were able to be observed with nanostar shape demonstrating the influence of the shape on enhancement of the SERS spectra [132].…”

Section: Single-cell Analysis and Surface-enhanced Raman Scatteringmentioning

confidence: 99%

Gold Nanoparticles in Single-Cell Analysis for Surface Enhanced Raman Scattering

2016

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Abstract:The need for new therapeutic approaches in the treatment of challenging diseases such as cancer, which often consists of a highly heterogeneous and complex population of cells, brought up the idea of analyzing single cells. The development of novel techniques to analyze single cells has been intensively studied to fully understand specific alternations inducing abnormalities in cellular function. One of the techniques used for single cell analysis is surface-enhanced Raman spectroscopy (SERS) in which a noble metal nanoparticle is used to enhance Raman scattering. Due to its low toxicity and biocompatibility, gold nanoparticles (AuNPs) are commonly preferred as SERS substrates in single cell analysis. The intracellular uptake, localization and toxicity issues of AuNPs are the critical points for interpretation of data since the obtained SERS signals originate from molecules in close vicinity to AuNPs that are taken up by the cells. In this review, the AuNP-living cell interactions, cellular uptake and toxicity of AuNPs in relation to their physicochemical properties, and surface-enhanced Raman scattering from single cells are discussed.

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Section: Single-cell Analysis and Surface-enhanced Raman Scatteringmentioning

confidence: 99%

Gold Nanoparticles in Single-Cell Analysis for Surface Enhanced Raman Scattering

2016

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“…131,132 AuNF were synthesized in DES for use in SERS. 133 While reduction of HAuCl 4 occurred at any significant DES concentration, flower-like structures occurred at higher DES percentages as the weakened protection of the growing gold structures by the solvent rather than water allowed for branch formation along the (111), ( 200), (311) and (222) facets. As DES percentage increased above 10% multipod morphologies were observed instead.…”

Section: Ionic Liquids and Deep Eutectic Solventsmentioning

confidence: 99%

Bespoke nanostars: synthetic strategies, tactics, and uses of tailored branched gold nanoparticles

Siegel

Baker

2021

Nanoscale Adv.

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“…The enhancement factor produced by these gold nanoflowers was estimated to be 1.09 × 10 5 regarding pure RhB. The value of the enhancement factor is up to par with the intensively branched gold nanoparticles and is even greater than some of the reported gold nanostars and nanoflowers [ 96 ]. Concerning the biocompatibility of the nanomaterials synthesized using DESs, only a couple of studies has been carried out in vivo and in vitro.…”

Section: Reviewmentioning

confidence: 99%

The role of deep eutectic solvents and carrageenan in synthesizing biocompatible anisotropic metal nanoparticles

Das

Kumar

Rayavarapu

2021

Beilstein J. Nanotechnol.

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Plasmonic metal nanoparticles are widely used for many applications due to their unique optical and chemical properties. Over the past decade, anisotropic metal nanoparticles have been explored for imaging, sensing, and diagnostic applications. The variations and flexibility of tuning the size and shape of the metal nanoparticles at the nanoscale made them promising candidates for biomedical applications such as therapeutics, diagnostics, and drug delivery. However, safety and risk assessment of the nanomaterials for clinical purposes are yet to be made owing to their cytotoxicity. The toxicity concern is primarily due to the conventional synthesis route that involves surfactants as a structure-directing agent and as a capping agent for nanoparticles. Wet chemical methods employ toxic auxiliary chemicals. However, the approach yields monodispersed nanoparticles, an essential criterion for their intended application and a limitation of the green synthesis of nanoparticles using plant extracts. Several biocompatible counterparts such as polymers, lipids, and chitosan-based nanoparticles have been successfully used in the synthesis of safe nanomaterials, but there were issues regarding reproducibility and yield. Enzymatic degradation was one of the factors responsible for limiting the efficacy. Hence, it is necessary to develop a safer and nontoxic route towards synthesizing biocompatible nanomaterials while retaining morphology, high yield, and monodispersity. In this regard, deep eutectic solvents (DESs) and carrageenan as capping agent for nanoparticles can ensure the safety. Carrageenan has the potential to act as antibacterial and antiviral agent, and adds enhanced stability to the nanoparticles. This leads to a multidimensional approach for utilizing safe nanomaterials for advanced biomedical and clinical applications.

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Synthesis of gold nanoflowers using deep eutectic solvent with high surface enhanced Raman scattering properties

Cited by 23 publications

References 55 publications

Gold Nanoparticles in Single-Cell Analysis for Surface Enhanced Raman Scattering

Gold Nanoparticles in Single-Cell Analysis for Surface Enhanced Raman Scattering

Bespoke nanostars: synthetic strategies, tactics, and uses of tailored branched gold nanoparticles

The role of deep eutectic solvents and carrageenan in synthesizing biocompatible anisotropic metal nanoparticles

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