Synthesis of GnRH analogues and their application in targeted gene delivery systems

Yablokova, T. V.; Chelushkin, Pavel S.; Dorosh, Marina; Efremov, Alexander; Orlov, Sergey; Буров, С. В.

doi:10.1134/s1068162012010190

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Peptide Loadings In Polymer‐peptide Conjugates1

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2022

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Cited by 3 publications

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“…levulinic or pyruvic acids. Derivatives of pyruvic acid are of particular interest because of the formation of oximes and hydrazones endowed with enhanced stability at lowered pH . Here, we describe the interaction of aminooxy‐peptides with polyvinylpyrrolidone‐based polymers bearing pyruvoyl groups (4, 5), RGD‐peptide (6), and steroid (7) (Figure ).…”

Section: Peptide Loadings In Polymer‐peptide Conjugatesmentioning

confidence: 99%

Oxime ligation in acetic acid: efficient synthesis of aminooxy-peptide conjugates

et al. 2016

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Oxime ligation is a powerful tool in various bioconjugation strategies. Nevertheless, high reaction rates and quantitative yields are typically reported for aldehyde-derived compounds. In contrary, keto groups react much slower, with quantitative yields achieved at 5 h for low-molecular weight compounds and more than 15 h for polymers or dendrimers. In this communication, we report that oxime ligation proceeds rapidly with quantitative (>95%) conversion within 1.5-2 h in pure acetic acid. The practical utility of suggested technique is illustrated by the synthesis of peptide-steroid and peptide-polymer conjugates of model aminooxy-peptides. Copyright © 2016 European Peptide Society and John Wiley & Sons, Ltd.

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Section: Peptide Loadings In Polymer‐peptide Conjugatesmentioning

confidence: 99%