2018
DOI: 10.1111/1541-4337.12344
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Abstract: Galactooligosaccharides (GOS) are synthesized by the enzyme β-galactosidase during the hydrolysis of lactose. In this so-called transgalactosylation reaction the galactosyl moiety is transferred to another sugar molecule instead of water resulting in oligosaccharides of different chain lengths and glycosidic linkages. Because their structures are similar to oligosaccharides present in human breast milk, they act as prebiotics, which has been shown for infants and adults to be alike. While so far most of the r… Show more

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Cited by 69 publications
(29 citation statements)
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“…This is likely to be the reason to not having been found a high positive correlation between GOS and TTA, LAB and the initial lactose content, and a high negative correlation between GOS and pH. The ability of Lactobacillus spp., P. pentosaceus and P. acidilactici to synthesized GOS in fermented dairy media was reported by other authors [40][41][42][43]. However, observed differences between results in these studies are highly influenced by the type of microorganisms used and the initial substrate composition.…”
Section: Determination Of Lactose and Galactooligosaccharide (Gos) Comentioning
confidence: 75%
“…This is likely to be the reason to not having been found a high positive correlation between GOS and TTA, LAB and the initial lactose content, and a high negative correlation between GOS and pH. The ability of Lactobacillus spp., P. pentosaceus and P. acidilactici to synthesized GOS in fermented dairy media was reported by other authors [40][41][42][43]. However, observed differences between results in these studies are highly influenced by the type of microorganisms used and the initial substrate composition.…”
Section: Determination Of Lactose and Galactooligosaccharide (Gos) Comentioning
confidence: 75%
“…Namely, the obtained maximum GOS concentration in case of the immobilized preparation was achieved for 4 h, while the same GOS concentration with the soluble enzyme was achieved in 10 h. Therefore, it can be concluded that enzyme specificity shifted towards the reaction of transgalactosylation, bearing in mind that same hydrolytic activities of both preparations were employed in the reaction, and that 2.5‐fold enhancement of reaction productivity was achieved. Results of this study are important since there are a few examples of applied immobilized preparations for concentrated whey transformation (Jovanovic‐Malinovska et al ., ), although this reaction is already well established, as it can be seen in several review papers (Nath et al ., ; Fischer & Kleinschmidt, ).…”
Section: Resultsmentioning
confidence: 99%
“…In the preliminary stage of research, the reasoning of whey usage for GOS synthesis was tested under previously defined optimum conditions for the relevant enzyme (50 °C and pH 4.5). Since it is scientifically confirmed that higher lactose concentrations positively influence the GOS synthesis process (Gosling et al ., ; Vera et al ., ), and that the most successful studies considered using either concentrated or lactose supplemented whey and whey permeates (Fischer & Kleinschmidt, ), several initial whey concentrations (10–40% w/w) were examined (Fig. ).…”
Section: Resultsmentioning
confidence: 99%
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“…In situations where breastfeeding is not feasible, infant formula provides an alternative to mimic the nutritional composition of breastmilk 3 . Although bovine milk is mostly devoid of oligosaccharides, lactose based oligosaccharides can be produced in large quantities by incubation of various microbial β-galactosidases with high concentrations of lactose to catalyze transglycosylation reactions to produce galacto-oligosaccharides (GOS) 4 . The chemical composition of GOS components (i.e., linkage type, and degree of branching and degree of polymerization) is highly dependent of the reaction conditions, as well as the specific β-galactosidase enzyme used during production, which results in GOS preparations that are commonly a composite of multiple different oligosaccharides 5 .…”
Section: Introductionmentioning
confidence: 99%