Synthesis of Fused Isoquinolinone and Iminoisoindolinone Derivatives via a Copper‐Catalyzed Regioselective Switching Process

Abstract

Copper-catalyzed base switching procedures for the synthesis of various fused isoquinolinone derivatives and iminoisoindolinone derivatives from the same starting materials have been developed. In these reaction sequences it is found that benzyl cyanide acts as a nucleophile in the presence of strong bases while it acts as a cyanide donor in the presence of weak bases. A wide substrate scope, good functional group tolerance, and handy reaction conditions are the important features of these proto-cols. Futhermore, using these protocols a wide variety of imidazolone-fused isoquinolinone derivatives, pyrimidinone-fused isoquinolinone derivatives, a di-

Nickel-catalyzed C–O/N–H, C–S/N–H, and C–CN/N–H annulation of aromatic amides with alkynes: C–O, C–S, and C–CN activation

“… 12 We also examined the possibility of C–CN bond activation, which afforded the desired products. 13 …”

Synthesis of Unsymmetrical Urea Derivatives via Cu‐Catalyzed Reaction of Acylazide and Secondary Amine

“…Our group has been actively involved in the development of methodologies for the construction of heterocyclic molecules [40–42] . During the course of our studies, we need to prepare substituted urea derivatives.…”