This review describes the development in the use of Au(I)/Brønsted acid binary catalytic systems to enable an enantioselective transformation in one-pot that cannot be achieved by gold catalysts alone. The examples discussed herein are promising since apart from using chiral ligands there exists a possibility of using chiral Brønsted acids. Clearly, the horizon for enantioselective gold catalysis has been expanded as more options to make the gold-catalyzed reactions enantioselective have become available.

An enantioselective cooperative catalysis protocol, utilizing achiral Au(I) complexes and chiral Brønsted acids, has been developed for the synthesis of optically pure fused 1,2-dihydroisoquinolines starting from 2-alkynylbenzaldehydes and 2-aminobenzamides.

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Schrumpfende Strukturen: Mit dem Liganden 4‐(Pyridin‐4‐yl)pyridin‐2‐carbonsäure (ppca) gelang die Synthese des neuen 3D‐Netzwerks {[Co2(ppca)2(H2O)(V4O12)0.5]⋅3.62 H2O}n, das sich durch „dynamische Strukturänderungen“ auszeichnet. Durch Temperaturwechsel werden Gastmoleküle und/oder netzwerkgebundene Liganden wie H2O reversibel entfernt, womit eine reversible Strukturänderung einhergeht (siehe Schema).

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A concise route for the synthesis of indenoisoquinoline derivatives from 2-iodobenzamide and 1,3-indanedione derivatives in the presence of copper(II) chloride and cesium carbonate in acetonitrile solvent is reported. A wide variety of 2-iodobenzamide derivatives and indandiones could be used to synthesize indenoisoquinoline derivatives and other fused indenoisoquinoline in moderate to good yields. This methodology was adapted for the one-step synthesis of a series of clinically active topoisomerase I inhibitors such as NSC 314622, LMP-400, LMP-776.