Synthesis of Fluorine-18 Functionalized Nanoparticles for use as in vivo Molecular Imaging Agents

Abstract

General Information.NMR spectra were measured in CDCl 3 or DMSO-d6 on Varian Mercury 300MHz spectrometers unless otherwise noted. Measurements were made at 25 °C. Prior to analysis, solutions were centrifuged in aBeckman model TJ-6 centrifuge at 2000 rpm for 5 min to sediment dust particles.Scattered light was collected at a fixed angle of 90°. The digital correlator was operated with 250 ratio spaced channels, an initial delay of 5 µs, a final delay of 50 ms, and a duration of 10 min. The calculations of the particle size distributions and distribution averages were performed with the ISDA software package (Brookhaven Instruments Company), using CONTIN particle size distribution analysis routines. All measurements were made in triplicate.AFM images were taken using a Nanoscope IV Scanning Probe MicroscopeController (Digital Instruments, Veeco Metrology Group) in tapping mode in air at room

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