Synthesis of Fluorescent Titanium Nanoclusters at ambient temperature for highly sensitive and selective detection of Creatine Kinase MM in myocardial infarction

Dissanayake, Manusha; Wu, Di; Wu, Hui‐Fen

doi:10.1016/j.colsurfb.2022.112594

Cited by 8 publications

(4 citation statements)

References 83 publications

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“…187 Recently, Wu et al successfully demonstrated a new approach using fluorescent titanium nanoclusters (Ti NCs) for highly selective sensitive detection of CK-MM in myocardial infarction. 188 The sensing phenomenon of Ti NCs is the strong binding nature with the phosphate group of ATPS, in which the creatine was converted into phosphocreatine as shown in Figure 7c. This fluorescent sensing system was successfully applied for CK-MM detection in wide ranges from 0.625 U/L to 10 U/L, and the detection limit was as low as 0.2513 ng/mL in aqueous medium and 0.3465 ng/mL in human serum.…”

Section: Optical Signaling Readout-based Nanobiosensorsmentioning

confidence: 99%

“…Recently, Wu et al. successfully demonstrated a new approach using fluorescent titanium nanoclusters (Ti NCs) for highly selective sensitive detection of CK-MM in myocardial infarction . The sensing phenomenon of Ti NCs is the strong binding nature with the phosphate group of ATPS, in which the creatine was converted into phosphocreatine as shown in Figure c.…”

Section: Optical Signaling Readout-based Nanobiosensorsmentioning

confidence: 99%

Section: Optical Signaling Readout-based Nanobiosensorsmentioning

confidence: 99%

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Optical Nanobiosensor-Based Point-of-Care Testing for Cardiovascular Disease Biomarkers

Vairaperumal,

Huang,

Liu

2023

ACS Appl. Bio Mater.

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Cardiovascular disease is a global health threat, and detecting cardiac biomarkers is essential for early-stage diagnosis and personalized treatment. Traditional approaches have limitations, but optical nanobiosensors offer rapid, highly selective, and sensitive detection. Optical nanobiosensors generate biosignals that transfer light signals while analytes bind with the bioreceptors. Optical nanobiosensors have advantages such as ease of monitoring, low cost, a wide detection range, and high sensitivity without any interference. An optical nanobiosensor platform is a promising approach for point-of-care cardiac biomarker detection with a low detection limit. This review mainly focuses on the detection of cardiovascular disease biomarkers based on various optical nanobiosensor approaches that have been reported during the last five years, and we have categorized them based on optical signal readouts. A detailed discussion of the classification of cardiovascular disease biomarkers, design strategies of optical biosensors, types of optically active nanomaterials, types of bioreceptors, functionalization techniques, various assay types, and sensing mechanisms is presented. Then, we summarize the optical signaling readout-based various nanobiosensors systems for the detection of cardiovascular disease biomarkers. Finally, we summarize and conclude with the recent development of point-of-care testing (PoCT) for cardiovascular disease biomarkers used in various optical readout techniques.

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Section: Optical Signaling Readout-based Nanobiosensorsmentioning

confidence: 99%

Section: Optical Signaling Readout-based Nanobiosensorsmentioning

confidence: 99%

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Optical Nanobiosensor-Based Point-of-Care Testing for Cardiovascular Disease Biomarkers

Vairaperumal,

Huang,

Liu

2023

ACS Appl. Bio Mater.

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“…Recently, optical methods, particularly fluorescence-based techniques, have emerged as prominent tools for creatinine sensing due to their high selectivity, real-time analysis, and user-friendly instrumentation. – Probes such as quantum dots and metallic nanoparticles have shown potential, but their operation in only acidic or basic pH buffers restricts their use in biological samples. – Traditional organic fluorophores like pyrene, dansyl, fluorescein, and naphthalene derivatives have also been explored for creatinine detection, but their poor water solubility and susceptibility to minor changes in experimental conditions limit their utility. Furthermore, their use often necessitates the development of specialized probes, a complex and time-consuming process.…”

Section: Introductionmentioning

confidence: 99%

Al³⁺-Responsive Ratiometric Fluorescent Sensor for Creatinine Detection: Thioflavin-T and Sulfated-β-Cyclodextrin Synergy

Bais,

Singh

2023

ACS Appl. Bio Mater.

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Kidney disorders are a rising global health issue, necessitating early diagnosis for effective treatment. Creatinine, a metabolic waste product from muscles, serves as an ideal biomarker for kidney damage. The existing optical methods for creatinine detection often involve labor-intensive synthesis processes and present challenges with the aqueous solubility and sensitivity to experimental variations. In this study, we introduce a straightforward fluorescence "turn-on" ratiometric sensor system for creatinine detection in aqueous media with a limit of detection of 0.5 μM. The sensor is based on sulfated-β-cyclodextrin (SCD)-templated Haggregate of a commercially available, ultrafast rotor dye thioflavin-T (ThT). The Al 3+ ion-induced dissociation of ThT−SCD aggregates, followed by reassociation upon creatinine addition, generates a detectable signal. The modulation of monomer/aggregate equilibrium due to the disassembly/reassembly of the ThT−SCD system under Al 3+ /creatinine influence serves as the optimal strategy for ratiometric creatinine detection in aqueous media. Our sensor framework offers several advantages: utilization of the readily available dye ThT, which eliminates the need for a laborious synthesis of custom fluorescent probes; ratiometric sensing, which improves quantitative analysis accuracy; and compatibility with complex aqueous media. The sensor's practical utility has been successfully demonstrated in artificial urine samples. In summary, our sensor system represents a significant advancement in the rapid, selective, and sensitive detection of the clinically crucial bioanalyte creatinine, offering potential benefits for the early diagnosis and management of kidney disorders.

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Silica-coating of Ca14Al10Zn6O35:Mn4+ particles and their luminescence properties

Ito

Yamauchi

Nakashima

et al. 2023

Advanced Powder Technology

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Synthesis of Fluorescent Titanium Nanoclusters at ambient temperature for highly sensitive and selective detection of Creatine Kinase MM in myocardial infarction

Cited by 8 publications

References 83 publications

Optical Nanobiosensor-Based Point-of-Care Testing for Cardiovascular Disease Biomarkers

Optical Nanobiosensor-Based Point-of-Care Testing for Cardiovascular Disease Biomarkers

Al³⁺-Responsive Ratiometric Fluorescent Sensor for Creatinine Detection: Thioflavin-T and Sulfated-β-Cyclodextrin Synergy

Silica-coating of Ca14Al10Zn6O35:Mn4+ particles and their luminescence properties

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Synthesis of Fluorescent Titanium Nanoclusters at ambient temperature for highly sensitive and selective detection of Creatine Kinase MM in myocardial infarction

Cited by 8 publications

References 83 publications

Optical Nanobiosensor-Based Point-of-Care Testing for Cardiovascular Disease Biomarkers

Optical Nanobiosensor-Based Point-of-Care Testing for Cardiovascular Disease Biomarkers

Al3+-Responsive Ratiometric Fluorescent Sensor for Creatinine Detection: Thioflavin-T and Sulfated-β-Cyclodextrin Synergy

Silica-coating of Ca14Al10Zn6O35:Mn4+ particles and their luminescence properties

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Product

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Al³⁺-Responsive Ratiometric Fluorescent Sensor for Creatinine Detection: Thioflavin-T and Sulfated-β-Cyclodextrin Synergy