Synthesis of fibrinolytic active silver nanoparticle using wheat bran xylan as a reducing and stabilizing agent

Anti-candida, anti-coagulant and thrombolytic activities of biosynthesized silver nanoparticles using cell-free extract of Bacillus safensis LAU 13

“…However, it is not yet fully understood if AgNPs can inhibit activities of other factors that participate in the coagulation cascade such as factors II, VII, and X to prevent the formation of thrombin (factor IIa). The fibrinolytic activity of AgNPs as reported by Harish et al [16] showed that can inhibit or break down fibrin. Similarly, AgNPs can inhibit fibrinogen (factor I) at forming fibrin, and coupled with anti-platelet aggregation, the anticoagulant activity can be pronounced.…”

“…This was studied following the modified methods of Harish et al [16]. Human blood freely given by a healthy volunteer was used for the assays.…”

“…The use of conventional therapies such as heparin, tissue plasminogen activator, urokinase, or streptokinase in the management of thrombosis have been plagued with complications of bleeding associated with reocclusion and reinfarction [14][15]. Among the innovative nanotechnological approaches being sought for in the management of thrombosis is the use of nanoparticles either as thrombolytic or anti-platelet agents [14,16] or as carriers of other thrombolytic agents [17]. Other applications of nanoparticles are in the in vivo visualization of thrombi using magnetic resonance imaging and computed tomography [15].…”

Silver nanoparticle synthesis using lignin as reducing and capping agents: A kinetic and mechanistic study

“…Tannic acid [18], grape pomace extracts [1], Azadirachta indica leaf extract [13] and wheat bran xylan [4] have served as both reducing and capping agents to prepare silver nanoparticles. The silver nanoparticles so prepared tend to vary widely in shapes and sizes with coefficients of variation greater than 0.3, attributed to the structural and chemical complexity of these natural compounds [2,15,17,18].…”

Synthesis and characterization of crystalline carboxymethylated lignin–TEOS nanocomposites for metal adsorption and antibacterial activity

“…One of the plausible reasons of antibacterial activities of CML-Ts could be their nanoscale size and larger surface area of pathogen, due to which they could easily reach the nuclear content of bacteria (Shameli et al 2012). In the polymeric matrix, some researcher reported that silicate ions released from the surface of the composite are responsible for their antibacterial activity (Uppuluri et al 2015). Their mode of antimicrobial action may be related to their ability to inactivate microbial adhesions, enzymes, cell envelope transport proteins, etc.…”