Synthesis of Fe3O4-Gold hybrid nanoparticles coated by bovine serum albumin as a contrast agent in MR imaging

Danafar, Hossein; Baghdadchi, Yasamin; Barsbay, Murat; Ghaffarlou, Mohammadreza; Mousazadeh, Navid; Mohammadi, Ali

doi:10.1016/j.heliyon.2023.e13874

Cited by 10 publications

(10 citation statements)

References 20 publications

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“…Several advances in nanomaterial ferrites have made a great contribution to the biomedical field. Ferrites nanomaterials have the potential to increase the MRI contrast which was investigated by phantom MRI experiments showing that the signal intensity in MR images was significantly reduced, thus confirming the contrast ability of the formulated Fe 3 O 4 ‐Au‐BSA nanoparticles (NPs) 11. MNPs have been widely used for magnetically targeted drug delivery due to their magnetic properties, ease of surface modification, and low biotoxicity.…”

Section: Introductionmentioning

confidence: 83%

Synthesis Methods of Fe₃O₄ Nanoparticles for Biomedical Applications

et al. 2023

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Magnetic nanoparticles made from organic and inorganic materials have gained significant technological progress and are widely applied in biomedicine, including magnetic resonance imaging, targeted drug delivery systems, biosensors, hyperthermia, and tissue engineering. The most reported synthesis methods include hydrothermal, sol‐gel, laser ablation, microemulsion, and ball‐milling methods. The synthesis parameters have a strong correlation with essential properties, such as phase, size, and surface morphology, which greatly influence the macroscopic properties and potential applications of the particles. Different preparation methods result in magnetic nanoparticles with varying characteristics, and the appropriate method can be chosen based on the requirements of the specific application. Two effective methods for synthesizing magnetic nanoparticles are coprecipitation and hydrothermal method because the preparation is relatively simple with low energy consumption, and uniform and homogeneous crystals are obtained.

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Section: Introductionmentioning

confidence: 83%

Synthesis Methods of Fe₃O₄ Nanoparticles for Biomedical Applications

et al. 2023

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“…The obtained heterodimer colloids are stable for at least six months, while the preparations can be dried for long-term storage with the possibility of subsequent dissolution and use. This cost-effective simple synthesis strategy can be useful as a platform to preparation of various metal—metal oxide nanostructured materials for in particular targeted biomedical applications for example, as contrast agents when introducing magnetite into their composition [ 4 ]. Bactericide-containing colloidal heterodimer nanomaterials may be use as antibacterial agents to address the ever-increasing problem of antibiotic-resistant bacteria [ 86 ].…”

Section: Discussionmentioning

confidence: 99%

“…Lately, a focus has been on the conjugation of two or more nanomaterials to achieve increased multifunctionality as well as creating opportunities for the next generation materials (nanohybrids) with enhanced performance [ 1 , 2 ]. Among a variety of hybrid heterostructured materials, polyelement nanoparticles and metal-metal oxide heterostructures are widely studied and applied materials [ 2 , 3 , 4 ]. Great interest is caused by composites based on zinc oxide and metals—silver or gold.…”

Section: Introductionmentioning

confidence: 99%

One-Pot Synthesis of Colloidal Hybrid Au (Ag)/ZnO Nanostructures with the Participation of Maleic Acid Copolymers

et al. 2023

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One-pot synthesis of colloidal Au/ZnO and Ag/ZnO nanohybrid structures was carried out. The copolymers of maleic acid—poly(N-vinyl-2-pyrrolidone-alt-maleic acid), poly(ethylene-alt-maleic acid), or poly(styrene-alt-maleic acid) were used as templates for the sorption of cations of metals-precursors and stabilization of the resulting nanoheterostructures. Simultaneous production of two types of nanoparticles has been implemented under mild conditions in an aqueous alkaline medium and without additional reagents. Equimolar ratios of the metal cations and appropriate load on all copolymers were used: molar ratio of maleic acid monomeric units of copolymer/gold (silver)cations/zinc cations was 1/0.15/0.23 (1/0.3/0.15). The process of obtaining the heterostructures was studied using UV-Vis spectroscopy. The kinetics of the formation of heterostructures was influenced by the nature of the maleic acid copolymer and noble metal cations used. A high reaction rate was observed in the case of using zinc and gold cations-precursors and a copolymer of maleic acid with N-vinylpyrrolidone as a stabilizer of nanoparticles. The structure of the synthesized polymer-stabilized heterostructures was studied using instrumental methods of analysis—XPS, FTIR, PXRD, and TEM. Under the conditions used, stable colloidal solutions of heterodimers were obtained, and such structure can be converted to a solid state and back without loss of properties.

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“…Improving the biocompatibility of contrast agents requires surface modifications. Danafar et al 37 Superparamagnetic substances can decrease T2 relaxation time and boost a low T2 signal to a certain degree. Luo et al 38 created a nanoplatform consisting of IO@MnO 2 @DOX (IMD) hybrid NPs composed of superparamagnetic IO (SPION), manganese dioxide (MnO 2 ), and doxorubicin (DOX).…”

Section: Magnetic and Superparamagnetic Nano Mri Contrast Agentsmentioning

confidence: 99%

“…3 Nano-formulations have garnered significant attention in basic research into disease diagnosis and treatment owing to their unique properties, including enhanced permeability and retention (EPR) in solid tumors and surface modifiability. 4–47 Research into the development of more targeted nano-enhanced contrast agents aims to combine the potential advantages of nanomaterials to overcome the shortcomings of traditional small-molecule contrast agents, such as rapid metabolism and poor targeting. Improvement of the diagnostic ability and level of medical imaging has become an important research area in the preparation of medical imaging-enhanced contrast agents.…”

Section: Introductionmentioning

confidence: 99%

Advances in nanotechnology-based targeted-contrast agents for computed tomography and magnetic resonance

Lai,

Luo,

Chen

et al. 2024

Science Progress

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X-ray computed tomography (CT) and magnetic resonance (MR) imaging are essential tools in modern medical diagnosis and treatment. However, traditional contrast agents are inadequate in the diagnosis of various health conditions. Consequently, the development of targeted nano-contrast agents has become a crucial area of focus in the development of medical image-enhancing contrast agents. To fully understand the current development of nano-contrast agents, this review provides an overview of the preparation methods and research advancements in CT nano-contrast agents, MR nano-contrast agents, and CT/MR multimodal nano-contrast agents described in previous publications. Due to the physicochemical properties of nanomaterials, such as self-assembly and surface modifiability, these specific nano-contrast agents can greatly improve the targeting of lesions through various preparation methods and clearly highlight the distinction between lesions and normal tissues in both CT and MR. As a result, they have the potential to be used in the early stages of disease to improve diagnostic capacity and level in medical imaging.

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Synthesis of Fe3O4-Gold hybrid nanoparticles coated by bovine serum albumin as a contrast agent in MR imaging

Cited by 10 publications

References 20 publications

Synthesis Methods of Fe₃O₄ Nanoparticles for Biomedical Applications

Synthesis Methods of Fe₃O₄ Nanoparticles for Biomedical Applications

One-Pot Synthesis of Colloidal Hybrid Au (Ag)/ZnO Nanostructures with the Participation of Maleic Acid Copolymers

Advances in nanotechnology-based targeted-contrast agents for computed tomography and magnetic resonance

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Synthesis of Fe3O4-Gold hybrid nanoparticles coated by bovine serum albumin as a contrast agent in MR imaging

Cited by 10 publications

References 20 publications

Synthesis Methods of Fe3O4 Nanoparticles for Biomedical Applications

Synthesis Methods of Fe3O4 Nanoparticles for Biomedical Applications

One-Pot Synthesis of Colloidal Hybrid Au (Ag)/ZnO Nanostructures with the Participation of Maleic Acid Copolymers

Advances in nanotechnology-based targeted-contrast agents for computed tomography and magnetic resonance

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Synthesis Methods of Fe₃O₄ Nanoparticles for Biomedical Applications

Synthesis Methods of Fe₃O₄ Nanoparticles for Biomedical Applications