Synthesis of Evolvulus alsinoides derived gold nanoparticles for medical applications

Abstract

Plant mediated synthesis of metallic nanoparticles is an increasing commercial demand due to the wide applicability in various areas such as electronics, catalysis, chemistry, energy, cosmetics and medicine. This is greatly due to their special features, which include unusual optical and electronic properties, high stability and biological compatibility, controllable morphology and size dispersion, and easy surface functionalization. In the present investigation, synthesis of gold nanoparticle is done by using leaf extracts of Evolvulus alsinoides. Gold nanoparticles (AuNPs) were characterized by using UV visible absorption spectra. Their morphology, elemental composition and crystalline phase were determined by scanning electron microscopy, energy dispersive X-ray spectroscopy and FT-IR analysis was used to confirm the presence of gold nanoparticles in the extracts. The plant derived gold nanoparticles were also showing more inhibition activity in both bacterial and fungus strains. In bacteria, gram negative strains are highly affected by the test samples than gram positive. In fungal strains, the highest effect was noticed in Trichophyton rubrum while less effect was observed in Candida albicans.

A Recent Review on Synthesis, Characterization and Activities of Gold Nanoparticles Using Plant Extracts

“…18 Using E. alsinoides leaf extract, Anbarasu et al observed the generation of spherical GNP with a diameter of 80 nm using SEM. 43 DSL study revealed that size distribution of the synthesized GNPs were in the range of 50-100nm with the highest fraction of 80.29nm as shown in Figure 13b, which matched the results of the SEM analysis. Markus et al studied the synthesis of GNP utilising the Root of Chinese Herb A. pubescens Maxim.…”

“…Anbarasu et al produced spherical GNPs using E. alsinoides leaf at room temperature under dark condition. 43 With a zeta potential value of -28.7mV, these GNPs with an 80nm diameter showed good biocompatibility and stability for over 4 weeks as shown in Figure 11a. Gopinath et al manufactured GNPs utilizing T. arjuna fruit extract.…”

Recent advances in topical carriers of anti-fungal agents

“…Of AgNPs showing effect against the film Cytotoxicity assay with HepG2 cells Membrane damaging activity at fungicidal conc. Is not interfering with mammalian membrane Potent inhibitors and have good therapeutic potential [ 136 ] --------- ------------ Disc diffusion method Maximum activity against T. rubrum followed by C. albicans, C. tropicalis, and M. furfur ----- -------- [ 139 ] Gold Nanoparticles Candida Albicans Athlete's foot, rashes, Swelling and skin candidiasis ------------- ---------- Disc diffusion method against NCIM and MTCC microbes ---- ------ Potent inhibitors [ 141 ] Chitosan Nanoparticles Candida Albicans Skin candidiasis -------------- ------------ Microdilution suspectibility testing against C. albican ATCC 14053 Improve the liposome residence time and therapeutic effect ---------- --- High drug loading and potent inhibitors [ 142 ] Chitosan-silver nanoparticles composite Candida albicans, Candida spp. Skin candidiasis ------- ----- Liquid growth inhibition assay Fungal growth inhibition was significantly high ------ ----- Potential alternative for antifungal chemotherapy.…”

Wound Healing Activity of Plants from the Convolvulaceae Family

“…24 Gold nanoparticles produced using E. alsinoides also showed antimicrobial activity against S. typhimurium, Micrococcus luteus, and the fungus Trichophyton rubrum in the disk diffusion assay. 25…”