Synthesis of dual functional gallic-acid-based carbon dots for bioimaging and antitumor therapy

Lu, Shiqiang; Liu, Liping; Zhao, Wancheng; Li, Zeyu; Qu, Zhibin; Li, Jialu; Sun, Tiedong; Wang, Henan; Sui, Guangchao

doi:10.1039/c9bm00570f

Cited by 48 publications

(23 citation statements)

References 40 publications

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“…Nanomedicine. Besides being carriers, CDs themselves behave with therapeutic performances such as antibacterial activity, 60,181−183 anticancer activity, 184,185 antiviral activity, 186,187 and antioxidant activity. 188−190 Usually, using drug molecules (e.g., metronidazole, 60 gentamicin sulfate, 181 glycyrrhizic acid 187 ) as precursors, the as-prepared CPDs possess similar or superior therapeutic performances as compared to pristine drugs due to the retention of pharmacophores in their structures or the formation of new active structures.…”

Section: Biomedical Applicationsmentioning

confidence: 99%

Carbon Dots: A New Type of Carbon-Based Nanomaterial with Wide Applications

2020

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Carbon dots (CDs), as a new type of carbon-based nanomaterial, have attracted broad research interest for years, because of their diverse physicochemical properties and favorable attributes like good biocompatibility, unique optical properties, low cost, ecofriendliness, abundant functional groups (e.g., amino, hydroxyl, carboxyl), high stability, and electron mobility. In this Outlook, we comprehensively summarize the classification of CDs based on the analysis of their formation mechanism, micro-/nanostructure and property features, and describe their synthetic methods and optical properties including strong absorption, photoluminescence, and phosphorescence. Furthermore, the recent significant advances in diverse applications, including optical (sensor, anticounterfeiting), energy (light-emitting diodes, catalysis, photovoltaics, supercapacitors), and promising biomedicine, are systematically highlighted. Finally, we envisage the key issues to be challenged, future research directions, and perspectives to show a full picture of CDs-based materials.

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Section: Biomedical Applicationsmentioning

confidence: 99%

Carbon Dots: A New Type of Carbon-Based Nanomaterial with Wide Applications

2020

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“…Two main challenges for bioimaging of live cells are phototoxicity and photobleaching of materials used for it . CQDs have favorable properties for bioimaging: tunable PL, resistance to photobleaching, and very good biocompatibility. − Therefore, they can be good candidates for cell bioimaging. − CQDs are localized in the cell membrane or cytoplasm depending on the encapsulation/functionalization …”

Section: Introductionmentioning

confidence: 99%

Highly Efficient Antioxidant F- and Cl-Doped Carbon Quantum Dots for Bioimaging

Marković

Labudová

Danko

et al. 2020

ACS Sustainable Chem. Eng.

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The addition of heteroatoms to pristine carbon quantum dots (CQDs) change their structure and optical properties. In this study, fluorine (F)- and chlorine (Cl)-doped CQDs are prepared by the one-step green hydrothermal route from sodium fluoride, sodium chloride, urea, and citric acid as the starting precursors. Microscopy analysis reveals that the average size of these quantum dots is 5 ± 2 nm, whereas the chemical study shows the existence of C–F and C–Cl bonds. The produced F- and Cl-doped CQDs have fluorescence quantum yields of 0.151 and 0.284, respectively, at an excitation wavelength of 450 nm. Charge transfer resistance of F- and Cl-doped CQDs films is 2 orders of magnitude higher than in the pristine CQD films. Transport band gap of the doped CQDs is 2 eV bigger than that of pristine CQDs. Radical scavenging activity shows very good antioxidant activity of doped CQDs. Antibacterial testing reveals poor antibacterial activity against Staphylococcus aureus and Escherichia coli. The F- and Cl-doped CQDs are successfully used as fluorescent probes for cell imaging as shown by confocal microscopy.

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“…In this article, simple one-step microwave-assisted strategy 48,49 was adopted to synthesize the anticancer CDs. In a detail, GE (0.2 g) was added to deionized water (40 ml), which was preswelled for 72 h at room temperature in advance and warmed to 40 C under agitation.…”

Section: Synthesis and Characterization Of Ggcdsmentioning

confidence: 99%

“…44,45 GA and its derivatives(like methyl gallate) also have extraordinary antiproliferative activity in combination toward nonsmall cell lung cancer, nasopharyngeal carcinoma cells (NPC-BM1), and so on. 46,47 Our previous research 48 reported that GA was used as carbon resource and antitumor agent for preparing CDs with bioimaging and antitumor activity. In this study, a brand new sort of cancer CM-coated GA-based CDs (CM-GGCDs) is designed and prepared for in vitro-selective cell imaging and targeted therapy of the homotypic tumor.…”

Section: Introductionmentioning

confidence: 99%

Preparation of carbon dots‐based nanoparticles and their research of bioimaging and targeted antitumor therapy

Chen

Sui

et al. 2021

J Biomed Mater Res

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Carbon dots (CDs) are nanomaterials with excellent photoluminescence property, usually used in the field of bioimaging tumor cells. However, its practical applicability in cancer therapeutics is limited by CDs' insensitive surface properties to complicated tumor microenvironment in vivo. Herein, a new type of innovative biomimetic nanoparticles has been formed with HeLa cell membranes (CM) and multifunctional CDs containing antitumor and bioimaging activities. The CDs are prepared by a facile one-step microwave-assisted procedure. Gallic acid is used as carbon resource and

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Synthesis of dual functional gallic-acid-based carbon dots for bioimaging and antitumor therapy

Abstract: Functional gallic acid-based carbon dots (GACDs) exhibited decent imaging effects and anti-cancer activities in vivo.

Cited by 48 publications

References 40 publications

Carbon Dots: A New Type of Carbon-Based Nanomaterial with Wide Applications

Carbon Dots: A New Type of Carbon-Based Nanomaterial with Wide Applications

Highly Efficient Antioxidant F- and Cl-Doped Carbon Quantum Dots for Bioimaging

Preparation of carbon dots‐based nanoparticles and their research of bioimaging and targeted antitumor therapy

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