Preparation of carbon dots‐based nanoparticles and their research of bioimaging and targeted antitumor therapy

Abstract

Carbon dots (CDs) are nanomaterials with excellent photoluminescence property, usually used in the field of bioimaging tumor cells. However, its practical applicability in cancer therapeutics is limited by CDs' insensitive surface properties to complicated tumor microenvironment in vivo. Herein, a new type of innovative biomimetic nanoparticles has been formed with HeLa cell membranes (CM) and multifunctional CDs containing antitumor and bioimaging activities. The CDs are prepared by a facile one-step microwave-assisted procedure. Gallic acid is used as carbon resource and

The Application of Carbon Nanomaterials in Sensing, Imaging, Drug Delivery and Therapy for Gynecologic Cancers: An Overview

“…Lu et al synthesized drug-based CDs by microwave treatment of gallic acid (GA, one anticancer agent), which not only showed fluorescence properties but also retained the antitumor activity of GA [ 102 ]. After coupling with HeLa cell membranes as tumor targeting, the GA-based CDs had selective imaging effects and good antitumor activity on HeLa cells [ 103 ].…”

A Perspective on Using Organic Molecules Composing Carbon Dots for Cancer Treatment

“…The CDs were assumed to enter the cancer cell passively due to enhanced permeability and retention (EPR) influence 14 . However, a recent study that employs cancer membrane (CM) to encapsulate drug-loaded CDs for targeting cancer cells has explicitly shown the influence of surface moieties 107 . Thus, although CDs can enter cancer cells passively, the role of functional groups is more pronounced.…”

“…In addition, in vivo investigations using mice have shown the ability of CDs to reduce tumor weight. Interestingly, the CDs showed significantly lower side effects [14,107]. The CDs were assumed to enter the cancer cell passively due to enhanced permeability and retention (EPR) influence [14].…”

Investigation of Anticancer Therapy Using pH-Sensitive Carbon Dots-Functionalized Doxorubicin in Cubosomes

“…Cancer is one of the diseases with the highest mortality rate in the world due to challenges in early detection, rapid metastasis, and severe side effects. , Nanomedicine has revolutionized cancer treatment by offering novel strategies for drug delivery, diagnosis, and therapy monitoring, − with advantages of improving curative effect, targeting desirable sites, and reducing side effects. − With the recent advancements in nanomaterial development, carbon dots (CDs) have emerged as a new class of fluorescent nanomaterials, which possess excellent fluorescence properties and the ability to simultaneously carry multiple drugs through covalent bonds, owing to their diverse surface functional groups such as amino, carboxyl, and hydroxyl groups. , In comparison to traditional semiconductor quantum dots, CDs exhibit superior biocompatibility, low toxicity, minimal environment impact, abundant raw material sources, and cost-effective preparation methods . Furthermore, CDs offer several advantages, including resistance to fluorescence quenching, ease of surface modification, and stable fluorescence performance, making them widely applicable in biological imaging and drug delivery. − …”

“…6−8 With the recent advancements in nanomaterial development, carbon dots (CDs) have emerged as a new class of fluorescent nanomaterials, which possess excellent fluorescence properties and the ability to simultaneously carry multiple drugs through covalent bonds, owing to their diverse surface functional groups such as amino, carboxyl, and hydroxyl groups. 9,10 In comparison to traditional semiconductor quantum dots, CDs exhibit superior biocompatibility, low toxicity, minimal environment impact, abundant raw material sources, and cost-effective preparation methods. 11 Furthermore, CDs offer several advantages, including resistance to fluorescence quenching, ease of surface modification, and stable fluorescence performance, making them widely applicable in biological imaging and drug delivery.…”