Synthesis of disulfide-based biodegradable bridged silsesquioxane nanoparticles for two-photon imaging and therapy of cancer cells

Croissant, Jonas G.; Mauriello-Jimenez, Chiara; Maynadier, Marie; Cattoën, Xavier; Man, Michel Wong Chi; Raehm, Laurence; Mongin, Olivier; Blanchard‐Desce, Mireille; Garcia, Marcel; Gary‐Bobo, Magali; Maillard, Philippe; Durand, Jean‐Olivier

doi:10.1039/c5cc03736k

Cited by 62 publications

(58 citation statements)

References 36 publications

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“…The degraded products of biodegradable nanoparticles (NPs) should also to be biocompatible. Biodegradable nanomaterials include various polymer, [6] liposome, [12,13] silicon, [14,15] organically-doped silica, [2,3,5] and calcium phosphate nanosystems. [16,17] In addition, nano-objects of hydrodynamic diameter (HD) below 10 nm are excreted by the body via the renal clearance route which prevents the toxicity associated with the bio-accumulation of particles.…”

Section: Introductionmentioning

confidence: 99%

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Biodegradable Magnetic Silica@Iron Oxide Nanovectors with Ultra-Large Mesopores for High Protein Loading, Magnetothermal Release, and Delivery

Omar

Croissant

Alamoudi

et al. 2017

Journal of Controlled Release

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Abstract:The delivery of large cargos of diameter above 15 nm for biomedical applications has proved challenging since it requires biocompatible, stably-loaded, and biodegradable nanomaterials. In this study, we describe the design of biodegradable silica-iron oxide hybrid nanovectors with large mesopores for large protein delivery in cancer cells. The mesopores of the nanomaterials spanned from 20 to 60 nm in diameter and post-functionalization allowed the electrostatic immobilization of large proteins (e.g. mTFP-Ferritin, ~534 kDa). Half of the content of the nanovectors was based with iron oxide nanophases which allowed the rapid biodegradation of the carrier in fetal bovine serum and a magnetic responsiveness. The nanovectors released large protein cargos in aqueous solution under acidic pH or magnetic stimuli. The delivery of large proteins was then autonomously achieved in cancer cells via the silica-iron oxide nanovectors, which is thus a promising for biomedical applications.

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Section: Introductionmentioning

confidence: 99%

“…[1][2][3][4][5][6][7][8][9][10][11] The absence of particle biodegradability prevents almost always the approval of the food and drug administration (FDA) and other regulatory agencies to enter the pharmaceutical market. Non-degradable nanomaterials are indeed raising concerns of toxicity due to their uncontrolled bio-accumulation.…”

Section: Introductionmentioning

confidence: 99%

Biodegradable Magnetic Silica@Iron Oxide Nanovectors with Ultra-Large Mesopores for High Protein Loading, Magnetothermal Release, and Delivery

Omar

Croissant

Alamoudi

et al. 2017

Journal of Controlled Release

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“…Durand et al. developed a versatile process to design monodisperse tetra‐alkoxysilylated diamino‐diphenylbutadiene or porphyrin photosensitizer‐based SSQ nanospheres, 30 to 50 nm in size . In addition, one type of photosensitizer‐disulfide‐based biodegradable bridged SSQ nanomaterial was also fabricated for two‐photon‐excited imaging and the treatment of breast cancer cells.…”

Section: Advanced Applicationsmentioning

confidence: 99%

Silsesquioxane‐Containing Hybrid Nanomaterials: Fascinating Platforms for Advanced Applications

Dong

2019

Macro Chemistry & Physics

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Silsesquioxanes (SSQs), with the general formula, (RSiO1.5)n—where R stands for an organic group, such as alkyl, aryl, alkoxy, or H—are a type of molecular‐level organic/inorganic hybrid silica‐based material. These materials contain reactive or nonreactive organic moieties as well as inorganic Si–O–Si frameworks. In the past few years, extensive efforts have been made using SSQs to construct multifunctional nanocomposites with suitable properties for a range of applications. In this review, the recent various applications of SSQ‐containing hybrid materials are discussed, in addition to updates of the nanocomposite applications. Various physical structures and chemical reactions in SSQ‐based hybrid nanomaterials are emphasized with regard to applications in the field of polymer nanocomposites, catalysts, adsorption, sensors, and biomedicine. This review focuses on results reported in the recent five years (2013–2018).

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“…14 Furthermore, researchers have indicated the use of breakable disulfide-based silsesquioxane nanoparticles for in vitro two-photon imaging and drug delivery to cancer cells. 15–17 Vivero-Escoto et al have made degradable polysilsesquioxane nanoparticles using bis(trialkoxysilyl) derivatives of Gd(III) diethylenetriamine pentaacetate (Gd-DTPA) as efficient contrast agents for magnetic resonance imaging (MRI). 18 Additionally, Omar et al have shown that degradable silica nanovectors can be synthesized using ultralarge pores spanning from 20 to 60 nm in diameter with high protein loading capacity.…”

Section: Introductionmentioning

confidence: 99%

Redox-Responsive Polysulfide-Based Biodegradable Organosilica Nanoparticles for Delivery of Bioactive Agents

Moghaddam

Saikia

Yazdimamaghani

et al. 2017

ACS Appl. Mater. Interfaces

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Design and development of silica nanoparticles (SiO2 NPs) with a controlled degradation profile promises effective drug delivery with a predetermined carrier elimination profile. In this research, we fabricated a series of redox-responsive polysulfide-based biodegradable SiO2 NPs with low polydispersity and with variations in size (average diameters of 58 ± 7, 108 ± 11, 110 ± 9, 124 ± 9, and 332 ± 6 nm), porosity, and composition (disulfide vs tetrasulfide bonds). The degradation kinetics of the nanoparticles was analyzed in the presence of 8 mM glutathione (GSH), mimicking the intracellular reducing condition. Results indicate that porosity and core composition play the predominant roles in the degradation rate of these nanoparticles. The 108 nm mesoporous disulfide-based nanoparticles showed the highest degradation rate among all the synthesized nanoparticles. Transmission electron microscopy (TEM) reveals that nonporous nanoparticles undergo surface erosion, while porous nanoparticles undergo both surface and bulk erosion under reducing environment. The cytotoxicity of these nanoparticles in RAW 264.7 macrophages was evaluated. Results show that all these nanoparticles with the IC50 values ranging from 233 ± 42 to 705 ± 17 μg mL−1 do not have cytotoxic effect in macrophages at concentrations less than 125 μg mL−1. The degradation products of these nanoparticles collected within 15 days did not show cytotoxicity in the same macrophage cell line after 24 h of incubation. In vitro doxorubicin (DOX) release was examined in 108 nm mesoporous disulfide-based nanoparticles in the absence and presence of 8 mM GSH. It was shown that drug release depends on intracellular reducing conditions. Due to their ease of synthesis and scale up, robust structure, and the ability to control size, composition, release, and elimination, biodegradable SiO2 NPs provide an alternative platform for delivery of bioactive and imaging agents.

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Synthesis of disulfide-based biodegradable bridged silsesquioxane nanoparticles for two-photon imaging and therapy of cancer cells

Cited by 62 publications

References 36 publications

Biodegradable Magnetic Silica@Iron Oxide Nanovectors with Ultra-Large Mesopores for High Protein Loading, Magnetothermal Release, and Delivery

Biodegradable Magnetic Silica@Iron Oxide Nanovectors with Ultra-Large Mesopores for High Protein Loading, Magnetothermal Release, and Delivery

Silsesquioxane‐Containing Hybrid Nanomaterials: Fascinating Platforms for Advanced Applications

Redox-Responsive Polysulfide-Based Biodegradable Organosilica Nanoparticles for Delivery of Bioactive Agents

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