Synthesis of Dibenzo-Fused Seven-Membered Heterocycles via Copper-Catalyzed Cyclization of 2-Haloaniline Compounds

Abstract

A one-step synthesis of dibenzo-fused seven-membered nitrogen heterocycles from acetophenones/benzophenones and 2haloanilines, via a copper-catalyzed amination, was developed. The reaction involves amination followed by intramolecular cyclization.

A one-pot synthetic strategy for construction of the dibenzodiazepine skeleton via a transition metal-free process

“…Yin and Liang also developed synthetic methods to obtain dibenzodiazepines, respectively. 10,11 Similarly, transition metal catalysts played key roles in their systems. Thus, it is necessary to provide a concise, general and efficient protocol for combining dibenzodiazepine derivatives.…”