Synthesis of cyclodextrin-derived star poly(N-vinylpyrrolidone)/poly(lactic-co-glycolide) supramolecular micelles via host-guest interaction for delivery of doxorubicin

Ramesh, Kalyan; Balavigneswaran, Chelladurai Karthikeyan; Siboro, Sonita A.P.; Muthuvijayan, Vignesh; Lim, Kwon Taek

doi:10.1016/j.polymer.2020.123243

Cited by 16 publications

(13 citation statements)

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“…The supramolecular hydrogels self-assemble via cooperative and highly specific physical interactions that transiently cross-link the hydrophilic polymer chains. 11,12 Further, the supramolecular self-assembly inherently enables the shear-thinning property of the hydrogels, which helps avoid clogging of the gel in the needle. 13,14 Therefore, preparing a hydrogel that heals without any external stimulus would be advantageous.…”

Section: Introductionmentioning

confidence: 99%

“…On the other hand, noncovalent interactions such as ionic bonding, hydrogen bonding, supramolecular interactions, hydrophobic bonding, and chain entanglement have also been utilized to produce self-healing systems. The supramolecular hydrogels self-assemble via cooperative and highly specific physical interactions that transiently cross-link the hydrophilic polymer chains. , Further, the supramolecular self-assembly inherently enables the shear-thinning property of the hydrogels, which helps avoid clogging of the gel in the needle. , Therefore, preparing a hydrogel that heals without any external stimulus would be advantageous.…”

Section: Introductionmentioning

confidence: 99%

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Nanohybrid-Reinforced Gelatin-Ureidopyrimidinone-Based Self-healing Injectable Hydrogels for Tissue Engineering Applications

Balavigneswaran

Muthuvijayan

2021

ACS Appl. Bio Mater.

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The traditional hydrogels are prone to break due to the applied stress. The deformation of the implanted hydrogels would result in the loss of structural integrity, leading to the failure of hydrogel functionalities and tissue regeneration. Selfhealing hydrogels (AG-UPy), composed of oxidized alginate and ureidopyrimidinonefunctionalized gelatin (G-UPy), were developed to address this challenge. These selfhealing hydrogels possess two independent healing mechanisms, viz., Schiff base formation and UPy dimerization. These hydrogels were compared with oxidized alginate-gelatin (AG) hydrogels. AG-UPy hydrogels showed effective self-healing in a short time (about 2 min) after applying 800% strain, wherein recovery was not achieved with the AG hydrogel. However, the shear-thinning property of UPy made the AG-UPy hydrogel mechanically weaker than the AG hydrogel. To improve the mechanical strength of the AG-UPy hydrogel, we impregnated poly(ethylene glycol)poly(urethane)/cloisite nanohybrid (PEG-PU/C) to prepare the AG-UPy/PEG-PU/C hydrogel. The incorporation of PEG-PU/C resulted in a 20-fold increase in the compression strength compared to that of the AG-UPy hydrogel. The AG-UPy/PEG-PU/C hydrogels also showed rapid self-healing. Incorporating the nanohybrid improved the cell proliferation by 2-and 1.25-fold compared to that of the AG and AG-UPy hydrogels, respectively. Therefore, PEG-PU/C combined with the UPy-functionalized polymer could be used to modulate mechanical strength and self-healing and enhance cell proliferation.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Nanohybrid-Reinforced Gelatin-Ureidopyrimidinone-Based Self-healing Injectable Hydrogels for Tissue Engineering Applications

Balavigneswaran

Muthuvijayan

2021

ACS Appl. Bio Mater.

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“…In contrast, drug‐loaded micelles displayed significant toxicity against C6 cells. Hemolysis and coagulation studies supported the hemocompatibility of the formulation [20] …”

Section: Macrocyclesmentioning

confidence: 73%

Recent Updates on Supramolecular‐Based Drug Delivery – Macrocycles and Supramolecular Gels

Saji

2022

The Chemical Record

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Supramolecules‐based drug delivery has attracted significant recent research attention as it could enhance drug solubility, retention time, targeting, and stimuli responsiveness. Among the different supramolecules and assemblies, the macrocycles and the supramolecular hydrogels are the two important categories investigated to a greater extent. Here, we provide the most recent advancements in these categories. Under macrocycles, reports on drug delivery by cyclodextrins, cucurbiturils, calixarenes/pillararenes, crown ethers and porphyrins are detailed. The second category discusses the supramolecular hydrogels of macrocycles/polymers and low molecular weight gelators. The updated information provided could be helpful to advance R & D in this vital area.

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“…An amphiphilic block copolymer forms micelles when in contact with an aqueous vehicle via self-assembly, resulting in hydrophobic interactions wherein hydrophobic drugs can be encapsulated into the central core of micelles through hydrophobic interactions. 24–26 These novel carriers have been successfully investigated for the delivery of various anticancer drugs, such as paclitaxel, 27–29 doxorubicin, 30,31 methotrexate, 32,33 etc. , to improve their therapeutic efficacy.…”

Section: Introductionmentioning

confidence: 99%

Targeted delivery of capecitabine to colon cancer cells using nano polymeric micelles based on beta cyclodextrin

Ameli

Alizadeh

2022

RSC Adv.

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Synthesis of cyclodextrin-derived star poly(N-vinylpyrrolidone)/poly(lactic-co-glycolide) supramolecular micelles via host-guest interaction for delivery of doxorubicin

Cited by 16 publications

References 50 publications

Nanohybrid-Reinforced Gelatin-Ureidopyrimidinone-Based Self-healing Injectable Hydrogels for Tissue Engineering Applications

Nanohybrid-Reinforced Gelatin-Ureidopyrimidinone-Based Self-healing Injectable Hydrogels for Tissue Engineering Applications

Recent Updates on Supramolecular‐Based Drug Delivery – Macrocycles and Supramolecular Gels

Targeted delivery of capecitabine to colon cancer cells using nano polymeric micelles based on beta cyclodextrin

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