Targeted delivery of capecitabine to colon cancer cells using nano polymeric micelles based on beta cyclodextrin

Ameli, Hossein; Alizadeh, Nina

doi:10.1039/d1ra07791k

Cited by 35 publications

(12 citation statements)

References 64 publications

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“…Recently, the development of a pH-responsive copolymer to optimise the delivery of the anticancer drug capecitabine (CAP) using nano-PMs and cyclodextrin (CD) for the treatment of colon cancer was reported. The authors proved that the micelles with their pH sensitivity perfectly target colon cancer, thus delivering the drugs under control to colon tissues with a release above 80% [104]. Therefore, they are considered "smart" nanocarriers for the delivery of anticancer drugs and imaging agents for various therapeutic and diagnostic applications.…”

Section: Polymeric Micelles (Pms) As Favourable Organic Nanocarriers ...mentioning

confidence: 99%

Promising Therapeutic Strategies for Colorectal Cancer Treatment Based on Nanomaterials

Krasteva

Georgieva

2022

Pharmaceutics

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Colorectal cancer (CRC) is a global health problem responsible for 10% of all cancer incidences and 9.4% of all cancer deaths worldwide. The number of new cases increases per annum, whereas the lack of effective therapies highlights the need for novel therapeutic approaches. Conventional treatment methods, such as surgery, chemotherapy and radiotherapy, are widely applied in oncology practice. Their therapeutic success is little, and therefore, the search for novel technologies is ongoing. Many efforts have focused recently on the development of safe and efficient cancer nanomedicines. Nanoparticles are among them. They are uniquewith their properties on a nanoscale and hold the potential to exploit intrinsic metabolic differences between cancer and healthy cells. This feature allows them to induce high levels of toxicity in cancer cells with little damage to the surrounding healthy tissues. Graphene oxide is a promising 2D material found to play an important role in cancer treatments through several strategies: direct killing and chemosensitization, drug and gene delivery, and phototherapy. Several new treatment approaches based on nanoparticles, particularly graphene oxide, are currently under research in clinical trials, and some have already been approved. Here, we provide an update on the recent advances in nanomaterials-based CRC-targeted therapy, with special attention to graphene oxide nanomaterials. We summarise the epidemiology, carcinogenesis, stages of the CRCs, and current nanomaterials-based therapeutic approaches for its treatment.

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Section: Polymeric Micelles (Pms) As Favourable Organic Nanocarriers ...mentioning

confidence: 99%

Promising Therapeutic Strategies for Colorectal Cancer Treatment Based on Nanomaterials

Krasteva

Georgieva

2022

Pharmaceutics

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“…Formulation of Micelles. Blank and BUD-loaded micelles are developed by a solvent evaporation method using the methodology of Ameli and Alizadeh 37 The synthesized amphiphile and BUD were dissolved in acetone. Then, distilled water was added drop-wise, which resulted in the self-assembly of amphiphile and micelle formation.…”

Section: Materials and Experimental Sectionsmentioning

confidence: 99%

Caffeic Acid-Conjugated Budesonide-Loaded Nanomicelle Attenuates Inflammation in Experimental Colitis

Mishra¹,

Ahmad

Kanika³

et al. 2022

Mol. Pharmaceutics

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Ulcerative colitis is a multifactorial disease of the gastrointestinal tract which is caused due to chronic inflammation in the colon; it usually starts from the lower end of the colon and may spread to other portions of the large intestine, if left unmanaged. Budesonide (BUD) is a synthetically available second-generation corticosteroidal drug with potent local anti-inflammatory activity. The pharmacokinetic properties, such as extensive first-pass metabolism and quite limited bioavailability, reduce its therapeutic efficacy. To overcome the limitations, nanosized micelles were developed in this study by conjugating stearic acid with caffeic acid to make an amphiphilic compound. The aim of the present study was to evaluate the pharmacological potential of BUD-loaded micelles in a mouse model of dextran sulfate sodium-induced colitis. Micelles were formulated by the solvent evaporation method, and their physicochemical characterizations show their spherical shape under microscopic techniques like atomic force microscopy, transmission electron microscopy, and scanning electron microscopy. The in vitro release experiment shows sustained release behavior in physiological media. These micelles show cytocompatible behavior against hTERT-BJ cells up to 500 μg/mL dose, evidenced by more than 85% viable cells. BUD-loaded micelles successfully normalized the disease activity index and physical observation of colon length. The treatment with BUD-loaded micelles alleviates the colitis severity as analyzed in histopathology and efficiently, overcoming the disease severity via downregulation of various related cytokines (MPO, NO, and TNF-α) and inflammatory enzymes such as COX-2 and iNOS. Results of the study suggest that BUD-loaded nano-sized micelles effectively attenuate the disease conditions in colitis.

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“…In the late stage of the tumor, chemotherapy is advantageous but with significant side effects and drug resistance. 5 Pyroptosis is a programmed cell death caused by the cleavage of the key executive protein family Gasdermin through cysteine asparase on the selfrepressing C-terminus end. And several N-terminal domains of Gasdermin localize to the cell membrane and form nanoscaled pores with a size of 10-15 nm by oligomerization.…”

Section: Introductionmentioning

confidence: 99%

“…Surgery shows favorable efficacy in the early stages of CRC. In the late stage of the tumor, chemotherapy is advantageous but with significant side effects and drug resistance 5 …”

Section: Introductionmentioning

confidence: 99%

Gasdermin E plasmid DNA/indocyanine green coloaded hybrid nanoparticles with spatiotemporal controllability to induce pyroptosis for colon cancer treatment

et al. 2023

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Pyroptosis is an immunogenic cell death and would trigger robust antitumor immunity. However, due to cytoxicity of pyroptosis executors, Gasdermin family proteins, it is indispensable to construct tumor-specific vectors. Here, we report the development of a novel vector named lipid-coated poly(lactideco-glycolide) (PLGA) nanoparticles coloaded with Gasdermin E expressing plasmid DNA (GSDME-pDNA) with a heat-inducible mouse heat shock protein 70 (mHSP70) as the promoter and a photosensitizer indocyanine green (ICG) to activate the mHSP70 element. The cellular internalization and transfection rate of the vector were remarkably enhanced by photothermal treatment. And the mHSP70 promoter further improved the gene transfection rate for about 15-fold. With the combination of oxaliplatin (OXA), the mechanism switch between apoptosis and pyroptosis was fulfilled by cleavage of GSDME through activated caspase-3, which promoted damage-associated molecular patterns (DAMPs) release and increased the infiltration of immune cells at the tumor site. This combination strategy not only prominently inhibited the growth of the treated tumor, but also exhibited a lethal effect on the distal tumors. Besides, mouse colon cancer cell CT26 overexpressing GSDME after OXA treatment had the potential to be the preventive tumor vaccine. This study provides a novel thought and feasible method for the clinical treatment of colon cancer.

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Targeted delivery of capecitabine to colon cancer cells using nano polymeric micelles based on beta cyclodextrin

Abstract: Nano polymeric micelles (nano PMs) help to increase accessibility to tumor sites, decrease side effects and allow controlled drug dissemination over a long period of time.

Cited by 35 publications

References 64 publications

Promising Therapeutic Strategies for Colorectal Cancer Treatment Based on Nanomaterials

Promising Therapeutic Strategies for Colorectal Cancer Treatment Based on Nanomaterials

Caffeic Acid-Conjugated Budesonide-Loaded Nanomicelle Attenuates Inflammation in Experimental Colitis

Gasdermin E plasmid DNA/indocyanine green coloaded hybrid nanoparticles with spatiotemporal controllability to induce pyroptosis for colon cancer treatment

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