2017
DOI: 10.1007/978-981-10-4361-1_115
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Synthesis of Cross-Linking Chitosan-Hyaluronic Acid Based Hydrogels for Tissue Engineering Applications

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Cited by 10 publications
(10 citation statements)
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“…In the case of unmodified hyaluronic acid, the characteristics absorption bands are found at 1666 and 1659 cm −1 corresponding to the C-N stretching of amide I and amide II, respectively. Moreover, at 1619, 1417 and 1322 cm −1 the stretching of asymmetric and symmetric bands of carboxylate groups as well as the stretching of C-N can be distinguished [ 50 , 51 ]. Regarding the infrared spectra of oxidized hyaluronic acid, no relevant differences can be highlighted, as is reported in the literature [ 16 ].…”
Section: Resultsmentioning
confidence: 99%
“…In the case of unmodified hyaluronic acid, the characteristics absorption bands are found at 1666 and 1659 cm −1 corresponding to the C-N stretching of amide I and amide II, respectively. Moreover, at 1619, 1417 and 1322 cm −1 the stretching of asymmetric and symmetric bands of carboxylate groups as well as the stretching of C-N can be distinguished [ 50 , 51 ]. Regarding the infrared spectra of oxidized hyaluronic acid, no relevant differences can be highlighted, as is reported in the literature [ 16 ].…”
Section: Resultsmentioning
confidence: 99%
“…In order to confirm the formation of covalent crosslinks between the CMCh and HAox components of the printing mixture, the CMCh2/HAox4-HA0.4 formulation was characterized by FTIR spectroscopy (see Figure S2 ). The characteristic peaks corresponding to the functional groups of the CMCh and HAox/HA precursors were observed in the mixture [ 56 , 57 , 62 ], together with a band at 1653 cm −1 , which can be attributed to the stretching vibration of the C=N bond of the Schiff base formed by a reaction of amine and aldehyde groups. This indicates that covalent crosslinking was successfully achieved [ 63 , 64 , 74 ].…”
Section: Resultsmentioning
confidence: 99%
“…Chitosan is a great candidate for tissue engineering applications since it exhibits notable biological features such as great cytocompatibility and biodegradability, antibacterial, hemostatic, or muco-adhesive properties [ 54 , 55 ]. Specifically, a carboxymethyl chitosan derivative (CMCh) was selected because of its good solubility at physiological pH, which allows straightforward encapsulation of cells in the bio-ink [ 56 , 57 ] and avoids any neutralization or washing steps, commonly used for pure chitosan-based printing [ 28 , 49 , 58 , 59 ]. Hyaluronic acid (HA) is an important component of the extracellular matrix (ECM), which favors cell affinity and proliferation [ 60 , 61 ].…”
Section: Introductionmentioning
confidence: 99%
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“…Polymers have particularly attracted much attention in bioinspired approaches to develop materials such as protein-, peptide-, or polysaccharide-based hydrogels resembling the natural ECM, recombinant protein-based polymers as vector-building blocks, dendrimers as promising carriers for drug delivery or synthetic polymers. 43,[49][50][51][52][53] Finally, a new range of biomaterials named as "smart polymers" is also being explored which does not just provide an architectural support but actively participates in the formation of functional tissue. 15,18,19 These smart materials include those that show conformational changes in response to environmental stimuli (such as temperature, ionic strength, pH, or light) or those DDS incorporating exogenous stimuli such as soluble growth and differentiation factors or bioactive molecules that can be released after implantation.…”
Section: Biomaterialsmentioning
confidence: 99%