Synthesis of Chromone Functionalized Chitosan Polymer: Application/Screening of Its Physical Parameters

Abstract

Chitosan is naturally occurring, biodegradable, non-toxic, non-allergenic biopolysaccharide derived from chitin which turns viscous upon dissolution in mildly acidic medium. Artificially changed chitosan consolidating hydroxyl chromone was set up by responding 6-Hydroxy-4-oxo-4H-chromone-3-carbaldehyde with chitosan; it was found to have high specific and chelating proficiency towards transition metal ion at pH 1-8. Enhanced adsorption capacity and a strong affinity for Cu 2+ was observed as compared to Cd 2+ , Ni 2+ and Co 2+ at pH 4-6. Chitosan-hydroxyl-chromone was chemically synthesized and characterized by spectroscopic techniques. Potentiometric strategies affirmed the request of selectivity which was free of the physical form of chitosan-hydroxyl-chromone subsidiary. 1 H NMR outcomes recommended a level of substitution (DS) extending from 32.72 to 98.21%. Antimicrobial and antioxidant activity of chitosanhydroxyl-chromone within the series of synthesized compounds was evaluated. To improve the solubility of chitosan in water, we present a synthesis of chitosan-based chromone biopolymers and its applications in metal extractions.

Advances in chromone-based copper(ii) Schiff base complexes: synthesis, characterization, and versatile applications in pharmacology and biomimetic catalysis

“…Gaidhane et al used chitosan, which is a naturally occurring, environment-friendly bio-polysaccharide derived from chitin to synthesize a new chromone-based polymer 26. 82 Yang et al reported a new probe i.e., 6-ethoxychromone-3 carbaldehyde-(furanyl)hydrazone 33 with turn-on uorescence and colorimetric properties. 83 The dual functional probe 33 was designed by reuxing a mixture of furan-2-carbohydrazide 32 and 6-ethoxychromon-3-carbaldehyde 31 in acetonitrile for 24 hours (Scheme 9).…”

“…Gaidhane et al used chitosan, which is a naturally occurring, environment-friendly bio-polysaccharide derived from chitin to synthesize a new chromone-based polymer 26. 82 Polymer 26 was prepared by the treatment of 24 with chitosan 25 in deionized water ( Scheme 8 ). It displayed specific, selective, and pH-influenced chelating efficiency with Cu 2+ ions in comparison to Ni 2+ , Co 2+ , and Cd 2+ heavy metal ions.…”

Innovational combination of hetero-bifunctional N-PEG quinoline scaffolds derivatives with improved anticancer activity against breast and colon cancer cell lines and P-glycoprotein, cytochrome p450 enzyme activity prediction

“…PEG is the covalent link of nonpoisonous, hydrophilic polyethylene glycol (PEG) to dynamic pharmaceutical constituents [18]. The technology established from revolutionary work was conducted in the 1950s and 1960s on the coupling of polymers to protein.…”