Synthesis of Chiral β‐Aminomalonates from 2‐Chlorotetrafluoroethanesulfinyl Aldimines through the Mannich Reaction

Abstract

An efficient method for the synthesis of chiral β‐aminomalonates in good yields and with high diastereoselectivities was achieved through Mannich reactions between 2‐chlorotetrafluoroethanesulfinyl aldimines and dialkyl malonates in the presence of N‐trimethylsilylimidazole. Further transformation of the products gave the corresponding β‐lactams in good yields and with high optical purities.