The first example of copper-catalyzed
four-component coupling reaction
of aryl iodides, Se powder, secondary amines, and maleimides is developed.
This reaction provides an efficient and concise route to access aminoarylselenated
maleimides via double C–Se bonds and C–N bond formation.
The appealing features of this transformation are the use of Se powder
as a selenating reagent, a green catalytic system, a wide range of
substrate scope, and late-stage selenation of bioactive compounds.