Abstract:Abstract:The four-step conversion of a series of N-Boc-protected L-amino acid methyl esters into enantiopure N-Boc allylamines by a modified Julia olefination is described. Key steps include the reaction of a lithiated phenylalkylsulfone with amino esters, giving chiral β-ketosulfones, and the reductive elimination of related α-acetoxysulfones. The overall transformation takes place under mild conditions, with good yields, and without loss of stereochemical integrity, being in this respect superior to the conv… Show more
The review mainly focuses on the recent developments in preparing β-keto sulfones and their enormous synthetic applications. New prospects for the synthesis of β-keto thiosulfones have also been highlighted. Over...
The first Cu-catalyzed asymmetric allylic C–H amination of alkenes with N-aryl hydroxylamines has been developed. Metal-complexes isolation, ESI-MS analysis and the DFT calculations provided key insights on mechanistic pathway.
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