Synthesis of carbon‐14 and carbon‐13 labeled 3‐methyl‐6‐[3‐(trifluoro‐methyl)phenyl]‐1,2,4‐triazolo[4,3‐b]pyridazine

Abstract

SUMMARY%Methyl -6-[3-( t r i f 1 uoromethyl ) phenyl 1-1,2,4-triazolo [4,3-b] p y r i d a z i n e ($), c u r r e n t l y being evaluated as a p o t e n t i a l anxio- l y t i c agent was synthesized, l a b e l e d w i t h carbon-14 i n the 3-p o s i t i o n o f t h e t r i a z o l o nucleus. i n 67% radiochemical y i e l d w i t h s p e c i f i c a c t i v i t y o f 13.5mCi/mmol and r a d i o p u r i t y of g r e a t e r than 99%. The carbon-13 l a b e l e d compound was a l s o synthesized f o r absorption and metabolism studies.