Advances in Pyridazine Chemistry

Vibrational spectrum of pyridazine

“…13 Other potential applications are in the synthesis of polymers14 and uses based on its liquid crystal15 form and weak anti-ozonant activity. 16 In this work, we studied this system from a point of view basically experimental, showing new spectral data for its vibrational spectrum, and we also completed the analysis by using some theoretical treatment. Table 1 summarizes the available experimental and computational information on the structure of pyridazine.…”

A Novel Synthesis of Ferrocenylpyridazines

“…[5] The currently known approaches to the synthesis of aromatic pyridazines include: (1) [4+2] Cycloaddition of alkynes to 1,2,4,5-tetrazines followed by elimination of an N 2 molecule from the Diels-Alder type cycloadduct. [6] (2) [4+2] Cycloaddition of dichlorodiazadienes to alicyclic azomethines. [7] (3) Coupling of α,β-unsaturated 1,4-diketones with hydrazine.…”

Synthesis, NMR, IR spectroscopic and X-ray study of novel [pyridazin-3(2H)-one-6-yl]ferrocenes and related ferrocenophane derivatives. Study on ferrocenes. Part 14

“…For many years considerable attention has been paid to the chemistry and biological activity of pyridazines [2][3][4][5][6][7][8][9]. It has been shown, e.g., that 1,3-and 1,4-bis[pyridazin-3(2H)-one-6-yl]benzenes, 4,4 0 -bis[pyridazin-3(2H)-one-6-yl]biphenyl and 2,5-bis[pyridazin-3(2H)-one-6-yl]thiophene and some of their partly saturated derivatives display generally stronger phosphodiesterase (PDE-III) inhibition than the corresponding mono-pyridazinone and this enhanced biological activity originates from the closer to optimal separation of two interacting polar heterocyclic moieties [5].…”