Synthesis of Carbamide Derivatives Bearing Tetrahydroisoquinoline Moieties and Biological Evaluation as Analgesia Drugs in Mice

Qiu, Qianqian; Wang, Jingjie; Deng, Xin; Qian, Hai; Lin, Haiyan; Huang, Wenlong

doi:10.1002/ardp.201400455

Cited by 3 publications

(3 citation statements)

References 11 publications

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“…1 H NMR (600 MHz, CDCl 3 ): δ 7.78 (q, J = 3.8, 2.9 Hz, 1H), 7.42–7.00 (m, 2H), 4.10 (s, 2H), 3.14 (q, J = 4.3, 2.8 Hz, 2H), 3.04 (t, J = 5.7 Hz, 2H), 1.93 (br s, 1H). Analytical data were identical to those reported in the literature …”

Section: Methodsmentioning

confidence: 51%

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General and Efficient Copper-Catalyzed Oxazaborolidine Complex in Transfer Hydrogenation of Isoquinolines under Mild Conditions

Liu

Zhou

2020

ACS Omega

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A general and efficient method for copper-catalyzed transfer hydrogenation of isoquinolines with an oxazaborolidine–BH 3 complex, under mild reaction conditions, is successfully developed. A broad range of isoquinolines has been reduced to the corresponding products with 61–85% yields. The method is applied to the synthesis of biologically active tetrahydrosioquinoline alkaloid (±)-norlaudanosine in 62% yield, which is the key precursor for the preparation of (±)-laudanosine, (±)- N -methyl-laudanosine, and (±)-xylopinine in one or two steps.

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Section: Methodsmentioning

confidence: 51%

“…Analytical data were identical to those reported in the literature. 43 5-Bromo-1,2,3,4-tetrahydroisoquinoline (2c). Colorless oil (80.2 mg, yield 76%).…”

Section: ■ Conclusionmentioning

confidence: 99%

General and Efficient Copper-Catalyzed Oxazaborolidine Complex in Transfer Hydrogenation of Isoquinolines under Mild Conditions

Liu

Zhou

2020

ACS Omega

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“…Increase aromatic amino acid decarboxylase activity, catechol-Omethyl-transferase-inhibitro, methyl donor, methyl guanidine inhibitor. Antithrombotic activity [20], Free radical scavenger and inhibitor of glutamate induced excitotoxicity [21], analgesic [22], antihypertensive [23] and antiviral [24] 6.…”

Section: Discussionmentioning

confidence: 99%

Profiling of bioactive chemical entities in Barleria buxifolia L. using GC-MS analysis – a significant ethno medicinal plant

S¹,

Senguttuvan²,

Thekan³

et al. 2017

J. Ayu. Her. Med.

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The present study was designed at to ascertain the plausible bioactive compounds of the aerial methanolic extract of Barleria buxifolia via GC-MS analysis which is used as a noteworthy ethnomedicinal plant for treating various diseases. The peaks perceived in the mass spectra were identified as compounds and were matched with the National Institute of Standards and Technology and Wiley library. Identified compounds were predicted for its activity using PASS software. Interestingly, about 30 compounds were scrutinized with their retention time, molecular formula, molecular weight, peak area (%). Based on structure, activities were predicted. The GC-MS analysis unveiled the different kinds of bioactive compounds such as alkaloids, terpenoids, triterpenoids, esters, aliphatic ketones, β-carotene etc. In bioinformatics approach, using the software, Prediction Activity Spectra for Substances (PASS), pharmacological effects and drug likeness were determined for all the compounds precisely which endorse the traditional usage of B. buxifolia for the treatment of various kinds of diseases such as anti-inflammatory, antiulcer, antihypertensive, antiviral, antiobesity, antidiabetic, caridioprotectant, vasoprotector, spasmolytic, respiratory analeptic, carminative etc. It is inferred that the putative hits obtained from B. buxifolia could potentially serve as a launching pad for a hit-to-lead a novel drug development. Barleria buxifolia, Acanthaceae, GC-MS analysis, PASS prediction, Drug likeness, Activity.

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Novel benzodiazepines derivatives as analgesic modulating for Transient receptor potential vanilloid 1

Liu

Liao

Zhou

et al. 2018

Bioorganic & Medicinal Chemistry

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Synthesis of Carbamide Derivatives Bearing Tetrahydroisoquinoline Moieties and Biological Evaluation as Analgesia Drugs in Mice

Cited by 3 publications

References 11 publications

General and Efficient Copper-Catalyzed Oxazaborolidine Complex in Transfer Hydrogenation of Isoquinolines under Mild Conditions

General and Efficient Copper-Catalyzed Oxazaborolidine Complex in Transfer Hydrogenation of Isoquinolines under Mild Conditions

Profiling of bioactive chemical entities in Barleria buxifolia L. using GC-MS analysis – a significant ethno medicinal plant

Novel benzodiazepines derivatives as analgesic modulating for Transient receptor potential vanilloid 1

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