2013
DOI: 10.1002/jlcr.3025
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Synthesis of C‐13‐labeled atrazine

Abstract: Atrazine is a long-lasting herbicide that has been shown to affect hormone levels in amphibians. Using the C-13 labeled atrazine to detect its residue is effective and essential. This study presents three steps for the synthesis of [(13) C3 ]atrazine, which starts from [(13) C]urea, and results in the incorporation of C-13 atoms at the 1, 3 and 5 positions of the S-triazine ring of atrazine. The method prepares the product in an overall yield of 57.6% and chemical purity of 98.6%, for use as an internal standa… Show more

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Cited by 4 publications
(3 citation statements)
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“…During the synthesis process, a previous synthesis of the similar compound 13 C 3 -atrazine was used as a guide [24]. At the first step, 13 C 3 -cyanuric acid was produced from 13 C-urea through thermolysis and condensation at 200˝C.…”
Section: Discussionmentioning
confidence: 99%
“…During the synthesis process, a previous synthesis of the similar compound 13 C 3 -atrazine was used as a guide [24]. At the first step, 13 C 3 -cyanuric acid was produced from 13 C-urea through thermolysis and condensation at 200˝C.…”
Section: Discussionmentioning
confidence: 99%
“…Triazine-2,4,6-trione incorporating three 15 N isotopes was produced by condensation of urea containing two 15 N in kerosene and (NH 4 ) 2 SO 4 by heating at high temperature. 34,35 The trimerization of urea takes place at 180 C in kerosene, and produces 15 NH 3 gas, giving triazine-2,4,6-trione incorporating three 15 N stable isotopes in good yield (97%) as a white-brown precipitate. This 15 N-containing compound shows a strong singlet in the 15 Interestingly, the behavior of this coupling reaction differs from that of the 14 N-containing heterocyclic triazine-2,4,6-trione.…”
Section: Entrymentioning
confidence: 99%
“…9. -ContinuedCharacterization: MS and NMR analysis for atrazine synthesisAtrazine was synthesized by the methods as previously described 66. The crude product was characterized by mass spectrometry (TOF-MS-EI+) and proton nuclear magnetic resonance( 1 H4-NMR).…”
mentioning
confidence: 99%