Synthesis of brushite/polyethylene glycol cement for filler in bone tissue injuries

Abstract

The objective of this work was to produce brushite cement for orthopedic applications, based on the system wollastonite/phosphoric acid with the incorporation of polyethylene glycol (PEG) as a setting and processing additive. Brushite/PEG cement was obtained by the dissolution-precipitation method and its physicochemical properties were characterized by X-ray diffraction, compressive strength, porosimetry, and biological behavior (cell adhesion and bioactivity tests). The results indicated the formation of brushite cement with 21.4 MPa of compressive strength and 30% porosity, similar to human trabecular bone. The surface was shown to be adequate for cell adhesion and growth and bioactive with the formation of apatite layers. The incorporation of PEG improved working conditions without causing undesirable changes in the physicochemical properties and biological behavior of developed cement, thus promising for the repair of bone tissue injuries.

Carbonate-Hydroxyapatite Cement: The Effect of Composition on Solubility In Vitro and Resorption In Vivo

“…Materials based on dicalcium phosphate dihydrate (DCPD) were resorbed faster in vivo, unlike materials based on apatite [31]. According to the results of experimental studies, materials based on DCPD have good biocompatibility [32][33][34].…”

Chitosan Effect on Hardening Dynamics of Calcium Phosphate Cement: Low-Field NMR Relaxometry Investigations

“…The liquid phase of the cement was composed of urethane dimethacrylate (UDMA)—an organic monomer with a large and rigid structure, which decreases the polymerization shrinkage; hydroxyethyl methacrylate (HEMA)—a viscosity modifier; and a synthetic polyethylene glycol polymer (PEG 400) with a low molecular weight; therefore, it is used as a solvent for a large number of substances that easily dissolve into water, but also as a solubilizing agent for active substances and excipients in liquid and semi-solid preparations, due to its low toxicity [ 19 ]. The incorporation of PEG improved the workability of the brushite cement without producing inadequate modifications in the physicochemical and biological properties [ 20 ].…”