Carbonate-Hydroxyapatite Cement: The Effect of Composition on Solubility In Vitro and Resorption In Vivo

Lukina, Yulia; Bionyshev-Abramov, Leonid; Kotov, Sergey; Serejnikova, Natalia B.; Смоленцев, Д. В.; Sivkov, S. P.

doi:10.3390/ceramics6030086

Cited by 3 publications

(2 citation statements)

References 49 publications

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“…The S3 sample presents a heterogeneous microstructure due to the complex filler system based on both TCP and nano HA mediated by chitosan additive, a fact supported by the EDX spectrum in Figure 6 d. Thus, two types of grains appear: polyhedral grains with very fine and compact microstructure inside them (these belong to the nano HA mixture with the polymer matrix, a fact sustained by the HA crystallites measured from the XRD pattern) and the clustered microstructure typical for TCP based on rounded clusters of about 3 ± 1.8 μm that are very well attached to the neighboring grains because of chitosan mediation between filler particles and UDMA hydrophobic monomers. The facts agree with the literature data [ 40 , 41 ].…”

Section: Resultssupporting

confidence: 93%

Mechanical Properties and Liquid Absorption of Calcium Phosphate Composite Cements

Lacan,

Moldovan,

Sarosi

et al. 2023

Materials

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Calcium phosphate cements present increased biocompatibility due to their chemical composition being similar to that of the hydroxyapatite in the hard tissues of the living body. It has certain limitations due to its poor mechanical properties, such as low tensile strength and increased brittleness. Thus, the optimal way to improve properties is through the design of novel composite cements. The purpose was fulfilled using a 25% hydroxyethyl methacrylate (HEMA) mixed with 3% urethane dimethacrzlate (UDMA) base matrix with various ratios of polyethylene glycol (PEG 400) and polycaprolactone (PCL). Mineral filler is based on tricalcium phosphate (TCP) with different chitosan ratio used as bio-response enhancer additive. Four mixtures were prepared: S0—unfilled polymer matrix; S1 with 50% TCP filler; S2 with 50% chitosan + TCP filler; and S3 with 17.5% chitosan + TCP mixed with 17.5% nano hydroxyapatite (HA). The mechanical properties testing revealed that the best compressive strength was obtained by S2, followed by S3, and the worst value was obtained for the unfilled matrix. The same tendency was observed for tensile and flexural strength. These results show that the novel filler system increases the mechanical resistance of the TCP composite cements. Liquid exposure investigation reveals a relative constant solubility of the used filler systems during 21 days of exposure: the most soluble fillers being S3 and S2 revealing that the additivated TCP is more soluble than without additives ones. Thus, the filler embedding mode into the polymer matrix plays a key role in the liquid absorption. It was observed that additive filler enhances the hydrophobicity of UDMA monomer, with the matrix resulting in the lowest liquid absorption values, while the non-additivated samples are more absorbent due to the prevalence of hydrolytic aliphatic groups within PEG 400. The higher liquid absorption was obtained on the first day of immersion, and it progressively decreased with exposure time due to the relative swelling of the surface microstructural features. The obtained results are confirmed by the microstructural changes monitored by SEM microscopy. S3 and S2 present a very uniform and compact filler distribution, while S1 presents local clustering of the TCP powder at the contact with the polymer matrix. The liquid exposure revealed significant pore formation in S0 and S1 samples, while S3 and S2 proved to be more resistant against superficial erosion, proving the best resistance against liquid penetration.

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Section: Resultssupporting

confidence: 93%

Mechanical Properties and Liquid Absorption of Calcium Phosphate Composite Cements

Lacan,

Moldovan,

Sarosi

et al. 2023

Materials

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“…New studies relating to the Mg alloy coatings for orthopaedic implants are also The crystallinity analysis presented here shows a coating comprising amorphous and distinct crystalline zones. The combination of these phases of ACP, OCP and some pure HA are desired for HA bone cement since these phases stimulate bone reformation in vitro [72,73]. New studies relating to the Mg alloy coatings for orthopaedic implants are also highlighting these ACP, OCP and HA phases as being beneficial for controlled resorption [74,75].…”

Section: The Growth Mechanism Of Ha Film On a Titanium Substratementioning

confidence: 99%

Development of Hydroxyapatite Coatings for Orthopaedic Implants from Colloidal Solutions: Part 2—Detailed Characterisation of the Coatings and Their Growth Mechanism

Murphy,

Morris,

Baez

2023

Nanomaterials

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This study is the second part of a two-part study whereby supersaturated solutions of calcium and phosphate ions generate well-defined hydroxyapatite coatings for orthopaedic implants. An ‘ideal’ process solution is selected from Part 1, and the detailed characterisation of films produced from this solution is undertaken here in Part 2. Analysis is presented on the hydroxyapatite produced, in both powder form and as a film upon titanium substrates representative of orthopaedic implants. From thermal analysis data, it is shown that there is bound and interstitial water present in the hydroxyapatite. Nuclear magnetic resonance data allow for the distinction between an amorphous and a crystalline component of the material. As hydroxyapatite coatings are generated, their growth mechanism is tracked across repeated process runs. A clear understanding of the growth mechanism is achieved though crystallinity and electron imaging data. Transmission electron imaging data support the proposed crystal growth and deposition mechanism. All of the data conclude that this process has a clear propensity to grow the hydroxyapatite phase of octacalcium phosphate. The investigation of the hydroxyapatite coating and its growth mechanism establish that a stable and reproducible process window has been identified. Precise control is achieved, leading to the successful formation of the desired hydroxyapatite films.

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Carbonate Hydroxyapatite - A Multifunctional Bioceramics with Non-Medical Applications

Adekanmi,

Garcia,

Lopez-Badillo

2024

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Carbonate hydroxyapatite is the common derivative of hydroxyapatite found in living systems. It is the building block of most hard tissues, including the teeth and bones. A vast majority of the applications of this versatile material focus on its biomedical applications, which is attributable to its closeness to biological apatites. Hydroxyapatite is a strong precursor to carbonate apatite in nature, and many experiments show that both are similar in a few respects. A significant divergence point is carbonate's obvious impact on its physicochemical properties and concomitant applications. The inclusion of carbonate ions into the lattice of hydroxyapatite results in morphological and physicochemical changes that vary with the method of synthesis and extent of substitution. The unique crystal structure, improved surface area, and porous morphology of carbonate hydroxyapatites also make it useful for catalysis and environmental remediation as adsorbents for heavy metals. This review briefly examines carbonate hydroxyapatite, its synthesis, its modification, and its characterization. It also highlights its biomedical applications while drawing attention to its non-medical potential.

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Carbonate-Hydroxyapatite Cement: The Effect of Composition on Solubility In Vitro and Resorption In Vivo

Cited by 3 publications

References 49 publications

Mechanical Properties and Liquid Absorption of Calcium Phosphate Composite Cements

Mechanical Properties and Liquid Absorption of Calcium Phosphate Composite Cements

Development of Hydroxyapatite Coatings for Orthopaedic Implants from Colloidal Solutions: Part 2—Detailed Characterisation of the Coatings and Their Growth Mechanism

Carbonate Hydroxyapatite - A Multifunctional Bioceramics with Non-Medical Applications

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