Synthesis of bone implant substitutes using organic additive based zirconia nanoparticles and their biodegradation study

Bashir, Mahwish; Riaz, Saira; Kayani, Zohra Nazir; Naseem, Shahzad

doi:10.1016/j.jmbbm.2018.07.035

Cited by 14 publications

(9 citation statements)

References 56 publications

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“…In other words, although surface modification can improve osseointegration, it does not have stability and long-term benefits [ 32 , 33 , 34 ]. The FHA film has proved to be a good bioactive coating [ 35 , 36 ], but the stability and uniformity of the film, the complexity of the coating approaches, and the practicability are limitations [ 37 , 38 ].…”

Section: Discussionmentioning

confidence: 99%

Structural Characterization and Osseointegrative Properties of Pulsed Laser-Deposited Fluorinated Hydroxyapatite Films on Nano-Zirconia for Implant Applications

Komasa

Hontsu

et al. 2022

IJMS

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Standard zirconia implants used in restoration still present problems related to inertness and long-term stability. Various physicochemical approaches have been used to modify the implant surfaces to improve early and late bone-to-implant integration; however, no ideal surface modification has been reported. This study used pulsed laser deposition to deposit a fluorinated hydroxyapatite (FHA) film on a zirconia implant to create a biologically active surface. The film prepared was uniform, dense, and crack-free, and exhibited granular surface droplets; it also presented excellent mechanical strength and favorable biological behavior. The FHA-coated implant was implanted on the femur of Sprague–Dawley rats, and various tests and analyses were performed. Results show that the in vitro initial cell activity on the FHA-coated samples was enhanced. In addition, higher alkaline phosphatase activity and cell mineralization were detected in cells cultured on the FHA-coated groups. Further, the newly formed bone volume of the FHA-coated group was higher than that of the bare micro-adjusted composite nano-zirconia (NANOZR) group. Therefore, the FHA film facilitated osseointegration and may improve the long-term survival rates of dental implants, and could become part of a new treatment technology for implant surfaces, promoting further optimization of NANOZR implant materials.

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Section: Discussionmentioning

confidence: 99%

Structural Characterization and Osseointegrative Properties of Pulsed Laser-Deposited Fluorinated Hydroxyapatite Films on Nano-Zirconia for Implant Applications

Komasa

Hontsu

et al. 2022

IJMS

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“…To enhance the mechanical properties and refine the osteoconductivity of bone cement additives, Gillani et al developed functionalized zirconia nanoparticles ( Gillani et al, 2010 ). To reduce the inertness of the zirconia, Bashir et al developed organic, additive-based zirconia nanoparticles as bone replacements ( Bashir et al, 2018 ). Due to the low expense of glucose and fructose, they employed them as organic additives.…”

Section: Current Developments Of Nanotechnology In Orthopedic Implantsmentioning

confidence: 99%

Current developments and future perspectives of nanotechnology in orthopedic implants: an updated review

Liang,

Zhou,

Bai

et al. 2024

Front. Bioeng. Biotechnol.

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Orthopedic implants are the most commonly used fracture fixation devices for facilitating the growth and development of incipient bone and treating bone diseases and defects. However, most orthopedic implants suffer from various drawbacks and complications, including bacterial adhesion, poor cell proliferation, and limited resistance to corrosion. One of the major drawbacks of currently available orthopedic implants is their inadequate osseointegration at the tissue-implant interface. This leads to loosening as a result of immunological rejection, wear debris formation, low mechanical fixation, and implant-related infections. Nanotechnology holds the promise to offer a wide range of innovative technologies for use in translational orthopedic research. Nanomaterials have great potential for use in orthopedic applications due to their exceptional tribological qualities, high resistance to wear and tear, ability to maintain drug release, capacity for osseointegration, and capability to regenerate tissue. Furthermore, nanostructured materials possess the ability to mimic the features and hierarchical structure of native bones. They facilitate cell proliferation, decrease the rate of infection, and prevent biofilm formation, among other diverse functions. The emergence of nanostructured polymers, metals, ceramics, and carbon materials has enabled novel approaches in orthopaedic research. This review provides a concise overview of nanotechnology-based biomaterials utilized in orthopedics, encompassing metallic and nonmetallic nanomaterials. A further overview is provided regarding the biomedical applications of nanotechnology-based biomaterials, including their application in orthopedics for drug delivery systems and bone tissue engineering to facilitate scaffold preparation, surface modification of implantable materials to improve their osteointegration properties, and treatment of musculoskeletal infections. Hence, this review article offers a contemporary overview of the current applications of nanotechnology in orthopedic implants and bone tissue engineering, as well as its prospective future applications.

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“…The team used glucose and fructose as organic additives because of their low cost. 164 However, zirconia nanoparticles have also been reported to have mild toxic effects. 165 Ye et al 131 determined that both zirconia and titania nanoparticles could induce apoptosis and morphology changes to osteoblast MC3T3-E1 cells.…”

Section: Tantalum (Ta) and Tantalum Oxide (Ta 2 O 5 ) Nanoparticlesmentioning

confidence: 99%

“…Gillani et al 163 prepared functionalized zirconia nanoparticles as bone cement additives, and reported refined osteoconductivity and improved mechanical properties. Bashir et al 164 created organic, additive‐based zirconia nanoparticles as bone substitutes to minimize the inertness of the zirconia. The team used glucose and fructose as organic additives because of their low cost 164 …”

Section: Various Metallic and Metallic Oxide Nanoparticles Used In Or...mentioning

confidence: 99%

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Functions and applications of metallic and metallic oxide nanoparticles in orthopedic implants and scaffolds

2020

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Bone defects and diseases are devastating, and can lead to severe functional deficits or even permanent disability. Nevertheless, orthopedic implants and scaffolds can facilitate the growth of incipient bone and help us to treat bone defects and diseases. Currently, a wide range of biomaterials with distinct biocompatibility, biodegradability, porosity, and mechanical strength is used in bone-related research. However, most orthopedic implants and scaffolds have certain limitations and diverse complications, such as limited corrosion resistance, low cell proliferation, and bacterial adhesion. With recent advancements in materials science and nanotechnology, metallic and metallic oxide nanoparticles have become the subject of significant interest as they offer an ample variety of options to resolve the existing problems in the orthopedic industry. More importantly, these nanoparticles possess unique physicochemical and mechanical properties not found in conventional materials, and can be incorporated into orthopedic implants and scaffolds to enhance their antimicrobial ability, bioactive molecular delivery, mechanical strength, osteointegration, and cell labeling and imaging. However, many metallic and metallic oxide nanoparticles can also be toxic to nearby cells and tissues. This review article will discuss the applications and functions of metallic and metallic oxide nanoparticles in orthopedic implants and bone tissue engineering.

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Synthesis of bone implant substitutes using organic additive based zirconia nanoparticles and their biodegradation study

Cited by 14 publications

References 56 publications

Structural Characterization and Osseointegrative Properties of Pulsed Laser-Deposited Fluorinated Hydroxyapatite Films on Nano-Zirconia for Implant Applications

Structural Characterization and Osseointegrative Properties of Pulsed Laser-Deposited Fluorinated Hydroxyapatite Films on Nano-Zirconia for Implant Applications

Current developments and future perspectives of nanotechnology in orthopedic implants: an updated review

Functions and applications of metallic and metallic oxide nanoparticles in orthopedic implants and scaffolds

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