Synthesis of Block Copolymer Brush by RAFT and Click Chemistry and Its Self-Assembly as a Thin Film

Thankappan, Hajeeth; Semsarilar, Mona; Li, Suming; Chang, Yung; Bouyer, Denis; Quémener, Damien

doi:10.3390/molecules25204774

Cited by 4 publications

(4 citation statements)

References 43 publications

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“…Thankappan et al [49] have prepared graft copolymers via the "grafting on" method by synthesizing the backbone and the side chains and then grafting them via "click chemistry". The group separately prepared POEGMA-b-PMMA and PGMA via CPADB CTA, with rather low molecular mass and narrow M w /M n .…”

Section: Graft Copolymersmentioning

confidence: 99%

Using RAFT Polymerization Methodologies to Create Branched and Nanogel-Type Copolymers

Skandalis,

Sentoukas,

Selianitis

et al. 2024

Materials

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This review aims to highlight the most recent advances in the field of the synthesis of branched copolymers and nanogels using reversible addition-fragmentation chain transfer (RAFT) polymerization. RAFT polymerization is a reversible deactivation radical polymerization technique (RDRP) that has gained tremendous attention due to its versatility, compatibility with a plethora of functional monomers, and mild polymerization conditions. These parameters lead to final polymers with good control over the molar mass and narrow molar mass distributions. Branched polymers can be defined as the incorporation of secondary polymer chains to a primary backbone, resulting in a wide range of complex macromolecular architectures, like star-shaped, graft, and hyperbranched polymers and nanogels. These subcategories will be discussed in detail in this review in terms of synthesis routes and properties, mainly in solutions.

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Section: Graft Copolymersmentioning

confidence: 99%

Using RAFT Polymerization Methodologies to Create Branched and Nanogel-Type Copolymers

Skandalis,

Sentoukas,

Selianitis

et al. 2024

Materials

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“…The two polymers were clicked together to afford a narrow-dispersed comb copolymer with a M n = (3.4–12.5) kg⋅mol − 1 and Ð = 1.12–1.18. Later, a similar strategy was put into practice [ 207 ] by grafting an alkynyl-terminated polymer onto pendant azide groups of another macromolecule. To that end, glycidyl methacrylate was polymerized in the presence of 4-cyano-4(phenylcarbonothioylthio) pentanoic acid as a RAFT agent and treated with sodium azide and ammonium chloride to functionalize each monomer unit with an azide group.…”

Section: Post-modification Of Side-group Approachmentioning

confidence: 99%

“… Synthesis of poly(oligo(ethylene glycol) methyl ether methacrylate)- b -poly(methyl methacrylate) block copolymer by RAFT polymerization and its click reaction with poly(glycidyl methacrylate azide) to prepare a block copolymer brush [ 207 ]. …”

Section: Figures Schemes and Tablesmentioning

confidence: 99%

RAFT-Based Polymers for Click Reactions

Черникова

Kudryavtsev

2022

Polymers

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The parallel development of reversible deactivation radical polymerization and click reaction concepts significantly enriches the toolbox of synthetic polymer chemistry. The synergistic effect of combining these approaches manifests itself in a growth of interest to the design of well-defined functional polymers and their controlled conjugation with biomolecules, drugs, and inorganic surfaces. In this review, we discuss the results obtained with reversible addition–fragmentation chain transfer (RAFT) polymerization and different types of click reactions on low- and high-molar-mass reactants. Our classification of literature sources is based on the typical structure of macromolecules produced by the RAFT technique. The review addresses click reactions, immediate or preceded by a modification of another type, on the leaving and stabilizing groups inherited by a growing macromolecule from the chain transfer agent, as well as on the side groups coming from monomers entering the polymerization process. Architecture and self-assembling properties of the resulting polymers are briefly discussed with regard to their potential functional applications, which include drug delivery, protein recognition, anti-fouling and anti-corrosion coatings, the compatibilization of polymer blends, the modification of fillers to increase their dispersibility in polymer matrices, etc.

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“…The idea behind RAFT is reversible chain transfer taking place between a CTA and activated macroradical (Kim, Cho, et al, 2020; Thankappan et al, 2020; Zhang et al, 2021). CTAs bear the chemical thiocarbonylthio compounds with the universal structure Z–C(=S)–R that can reversibly react to a propagating radical (addition) to make a transitional radical that can dissociate into supplementary CTAs and radical species.…”

Section: Synthetic Strategies To Functionalize Nanomaterials By Polym...mentioning

confidence: 99%

Advances in design of polymer brush functionalized inorganic nanomaterials and their applications in biomedical arena

Dutta

Shreyash

Satapathy

et al. 2022

WIREs Nanomed Nanobiotechnol

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Grafting of polymer brush (assembly of polymer chains tethered to the substrate by one end) is emerging as one of the most viable approach to alter the surface of inorganic nanomaterials. Inorganic nanomaterials despite their intrinsic functional superiority, their applications remain restricted due to their incompatibility with organic or biological moieties vis‐à‐vis agglomeration issues. To overcome such a shortcoming, polymer brush modified surfaces of inorganic nanomaterials have lately proved to be of immense potential. For example, polymer brush‐modified inorganic nanomaterials can act as efficient substrates/platforms in biomedical applications, ranging from drug‐delivery to protein‐array due to their integrated advantages such as amphiphilicity, stimuli responsiveness, enhanced biocompatibility, and so on. In this review, the current state of the art related to polymer brush‐modified inorganic nanomaterials focusing, not only, on their synthetic strategies and applications in biomedical field but also the architectural influence of polymer brushes on the responsiveness properties of modified nanomaterials have comprehensively been discussed and its associated future perspective is also presented. This article is categorized under: Diagnostic Tools > In Vivo Nanodiagnostics and Imaging Therapeutic Approaches and Drug Discovery > Emerging Technologies Nanotechnology Approaches to Biology > Nanoscale Systems in Biology

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Synthesis of Block Copolymer Brush by RAFT and Click Chemistry and Its Self-Assembly as a Thin Film

Cited by 4 publications

References 43 publications

Using RAFT Polymerization Methodologies to Create Branched and Nanogel-Type Copolymers

Using RAFT Polymerization Methodologies to Create Branched and Nanogel-Type Copolymers

RAFT-Based Polymers for Click Reactions

Advances in design of polymer brush functionalized inorganic nanomaterials and their applications in biomedical arena

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