Synthesis of bismuth (III) salicylates in the precipitation reactions from solutions

Timakova, Evgeniya V.; Udalova, T. A.; Yukhin, Yu. M.

doi:10.1109/ifost.2008.4602993

Cited by 2 publications

(2 citation statements)

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“…In the same sense, no evidence of BSS degradation by AcAc was observed, but only the dissolution and dispersion of the BSS powder into smaller crystalline BSS particles, in comparison with the particles observed for the as-received BSS powder. This is in agreement with previous reports evidencing the dissolution, but no degradation, and later precipitation, of bismuth salicylates from mineral acid solutions [54].…”

Section: Discussionsupporting

confidence: 94%

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Bismuth subsalicylate incorporated in polycaprolactone-gelatin membranes by electrospinning to prevent bacterial colonization

Vidal-Gutiérrez¹,

Prado-Prone²,

Rodil³

et al. 2021

Biomed. Mater.

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Periodontitis is a chronic, multifactorial, inflammatory disease characterized by the progressive destruction of the periodontal tissues. Guided tissue regeneration (GTR), involving the use of barrier membranes, is one of the most successful clinical procedures for periodontal therapy. Nevertheless, rapid degradation of the membranes and membrane-related infections are considered two of the major reasons for GTR clinical failure. Recently, integration of non-antibiotic, antimicrobial materials to the membranes has emerged as a novel strategy to face the bacterial infection challenge, without increasing bacterial resistance. In this sense, bismuth subsalicylate (BSS) is a non-antibiotic, metal-based antimicrobial agent effective against different bacterial strains, that has been long safely used in medical treatments. Thus, the aim of the present work was to fabricate fibrillar, non-rapidly bioresorbable, antibacterial GTR membranes composed of polycaprolactone (PCL), gelatin (Gel), and BSS as the antibacterial agent. PCL-G-BSS membranes with three different BSS concentrations (2 wt./v%, 4 wt./v%, and 6 wt./v%) were developed by electrospinning and their morphology, composition, water wettability, mechanical properties, Bi release and degradation rate were characterized. The Cytotoxicity of the membranes was studied in vitro using human osteoblasts (hFOB) and gingival fibroblasts (HGF-1), and their antibacterial activity was tested against Aggregatibacter actinomycetemcomitans, Escherichia coli, Porphyromonas gingivalis and Staphylococcus aureus. The membranes obtained exhibited adequate mechanical properties for clinical application, and appropriate degradation rates for allowing periodontal defects regeneration. The hFOB and HGF-1 cells displayed adequate viability when in contact with the lixiviated products from the membranes, and, in general, displayed antibacterial activity against the four bacteria strains tested. Thus, the PCL-G-BSS membranes showed to be appropriate as potential barrier membranes for periodontal GTR treatments.

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Section: Discussionsupporting

confidence: 94%

“…This broadband was also observed for the BSS-containing membranes. FTIR spectra of the BSScontaining membranes exhibited clear bands corresponding to BSS located at 1600 cm −1 (νC=O), 1420 cm −1 (ν as COO − ), and 864 cm −1 , 807 cm −1 , 704 cm −1 and 664 cm −1 (from Bi-O vibration) [54,55].…”

Section: Physical-chemical Properties Of the Membranesmentioning

confidence: 99%