Antimicrobial evaluation of bismuth subsalicylate nanoparticles synthesized by laser ablation against clinical oral microorganisms

Reyes-Carmona, Lorena; Camps, E.; Campos-González, E.; Mercado, Gabriela; Cervantes-Garduño, Alejandra; Pérez-Ibarra, Ezequiel A.; Álvarez-Chimal, Rafael; Rodil, Sandra E.; Almaguer‐Flores, Argelia

doi:10.1016/j.optlastec.2022.108930

Cited by 5 publications

(2 citation statements)

References 59 publications

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“…Besides, studies have shown that Ag nanoparticles (Ag-NPs) and Cu nanoparticles (Cu-NPs) have demonstrated higher inhibition percentages against oral bacteria compared to nanoparticles derived from bismuth or zirconium [ 74 – 77 ]. This highlights the superior antimicrobial properties of Ag and Cu in the context of oral bacteria.…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial activity of silver-copper coating against aerosols containing surrogate respiratory viruses and bacteria

Reyes-Carmona,

Sepúlveda-Robles,

Almaguer-Flores

et al. 2023

PLoS ONE

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The transmission of bacteria and respiratory viruses through expelled saliva microdroplets and aerosols is a significant concern for healthcare workers, further highlighted during the SARS-CoV-2 pandemic. To address this issue, the development of nanomaterials with antimicrobial properties for use as nanolayers in respiratory protection equipment, such as facemasks or respirators, has emerged as a potential solution. In this study, a silver and copper nanolayer called SakCu® was deposited on one side of a spun-bond polypropylene fabric using the magnetron sputtering technique. The antibacterial and antiviral activity of the AgCu nanolayer was evaluated against droplets falling on the material and aerosols passing through it. The effectiveness of the nanolayer was assessed by measuring viral loads of the enveloped virus SARS-CoV-2 and viability assays using respiratory surrogate viruses, including PaMx54, PaMx60, PaMx61 (ssRNA, Leviviridae), and PhiX174 (ssDNA, Microviridae) as representatives of non-enveloped viruses. Colony forming unit (CFU) determination was employed to evaluate the survival of aerobic and anaerobic bacteria. The results demonstrated a nearly exponential reduction in SARS-CoV-2 viral load, achieving complete viral load reduction after 24 hours of contact incubation with the AgCu nanolayer. Viability assays with the surrogate viruses showed a significant reduction in viral replication between 2–4 hours after contact. The simulated viral filtration system demonstrated inhibition of viral replication ranging from 39% to 64%. The viability assays with PhiX174 exhibited a 2-log reduction in viral replication after 24 hours of contact and a 16.31% inhibition in viral filtration assays. Bacterial growth inhibition varied depending on the species, with reductions ranging from 70% to 92% for aerobic bacteria and over 90% for anaerobic strains. In conclusion, the AgCu nanolayer displayed high bactericidal and antiviral activity in contact and aerosol conditions. Therefore, it holds the potential for incorporation into personal protective equipment to effectively reduce and prevent the transmission of aerosol-borne pathogenic bacteria and respiratory viruses.

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Section: Discussionmentioning

confidence: 99%

Antimicrobial activity of silver-copper coating against aerosols containing surrogate respiratory viruses and bacteria

Reyes-Carmona,

Sepúlveda-Robles,

Almaguer-Flores

et al. 2023

PLoS ONE

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“…When exposed to BSS-NPs, more than 30% of the total number of cultivable bacteria from the oral biofilm samples were suppressed. Because of this, BSS-NPs have the potential to be utilized as a novel alternative antibacterial in the treatment of periodontal disorders, lowering the usage of antibiotics without a prescription and halting the rise of antibiotic resistance [ 136 ]. This study investigated the effects of BiNPs on Enterococcus faecalis , the bacteria responsible for most chronic root canal infections.…”

Section: Metal Nanoparticles In Periodontitismentioning

confidence: 99%

Recent advances in metal nanoparticles to treat periodontitis

Nasiri,

Masoumi,

Amini

et al. 2023

J Nanobiotechnol

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The gradual deterioration of the supporting periodontal tissues caused by periodontitis, a chronic multifactorial inflammatory disease, is thought to be triggered by the colonization of dysbiotic plaque biofilms in a vulnerable host. One of the most prevalent dental conditions in the world, periodontitis is now the leading factor in adult tooth loss. When periodontitis does develop, it is treated by scraping the mineralized deposits and dental biofilm off the tooth surfaces. Numerous studies have shown that non-surgical treatment significantly improves clinical and microbiological indices in individuals with periodontitis. Although periodontal parameters have significantly improved, certain bacterial reservoirs often persist on root surfaces even after standard periodontal therapy. Periodontitis has been treated with local or systemic antibiotics as well as scaling and root planning. Since there aren't many brand-new antibiotics on the market, several researchers are currently concentrating on creating alternate methods of combating periodontal germs. There is a delay in a study on the subject of nanoparticle (NP) toxicity, which is especially concerned with mechanisms of action, while the area of nanomedicine develops. The most promising of them are metal NPs since they have potent antibacterial action. Metal NPs may be employed as efficient growth inhibitors in a variety of bacteria, making them useful for the treatment of periodontitis. In this way, the new metal NPs contributed significantly to the development of efficient anti-inflammatory and antibacterial platforms for the treatment of periodontitis. The current therapeutic effects of several metallic NPs on periodontitis are summarized in this study. This data might be used to develop NP-based therapeutic alternatives for the treatment of periodontal infections. Graphical Abstract

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