Synthesis of bioactive lipid A and analogs

Design, synthesis and immunological evaluation of monophosphoryl lipid A derivatives as adjuvants for a RBD-hFc based SARS-CoV-2 vaccine

“…These could provide practical access to structurally defined derivatives, contributing to structure-activity relationship analysis and structural modification. To date, many modified MPLA structures have been designed, synthesized and evaluated, 12,13,17 revealing the important characteristics that affect the bioactivity of MPLA, such as the number, length, saturation and branching of fatty chains. However, the impact of functional groups at the C-1, C-4′ or C-6′ position of MPLA has been rarely reported.…”