Synthesis of (±)-Bimatoprost

A Facile Route for the Synthesis of Novel Heterocyclic Prostaglandin F2α Analogs

“…Synthesis of key intermediate 6 was accomplished by us in seven linear steps starting from the racemic Corey lactone ( 8 ), and the details were reported earlier[6a]. Horner–Wadsworth–Emmons reaction of 6 with phosphonate ester 7 in the presence of sodium hydride (60%) in dimethoxyethane (DME) for 30 min at 0–5°C followed by ambient temperature for further 1.5 h afforded intermediates 5a , 5b , and the reaction conditions and yields are presented in Table .…”

“…) in three steps from the key intermediate through Horner–Wadsworth–Emmons reaction and Grignard reactions using various alkyl magnesium halides. Although α‐side chain is common for all these new analogs, the variations is common in ω‐side chain only. The details on the synthesis of versatile key intermediate ( 6 ) from (±)‐Corey lactone was reported by us, earlier [6a].…”

“…Although α‐side chain is common for all these new analogs, the variations is common in ω‐side chain only. The details on the synthesis of versatile key intermediate ( 6 ) from (±)‐Corey lactone was reported by us, earlier [6a].…”

A Facile Route for Synthesis of (±)-Dinoprost, (±)-Carboprost and Its Analogs

“…Recently attention has been focussed on Prostaglandin F2α esters [latanoprost (3), bimatoprost (4) and travoprost (5)] for the treatment of glaucoma [13][14][15][16] we have reported, recently, the general synthetic approach for synthesis of 3, 4 and 5 using common intermediate 7 [17][18][19] .…”

“…Synthesis of (±) dinoprost (1), (±) carboprost (2) and its analogs(16)(17)(18) from key intermediate(6) …”