Prostaglandins are a family of 20-carbon fatty acids found in virtually all mammalian cells 1,2. These are highly biologically active and have been implicated in the mediation of many physiological responses 3,4. Natural prostaglandins possess an allylic, secondary alcohol group at C-15 position. This alcohol group can be oxidized into a ketone in the presence of 15hydroxyprostaglandin dehydrogenase and this process is very rapid in vivo in animals and man 5-7. The oxidation to 15-ketoprostaglandins leads to the inactivation of prostaglandin
Oxadiazoles are important class of heterocycles due to their biological importance and are stable to physiological environment. 1,2,4-Oxadiazoles have often been used as bioisosteres of esters and amides 1 and are found in several drugs and drug leads 2 which includes potent sphingosine-1phosphate-1 (S1P1) agonist (I) 3 , the metabotropic glutamate subtype 5 (mGlu5) receptor (II) 4 and muscarinic receptor (III) 5 for the treatment of Alzheimer's diseases. They can also be found in a number of biologically important molecules, such as serotoninergic (5-HT 3) antagonists (IV) 6 , benzodiazepine receptor agonists (V) 7 and dopamine ligands (VI) 8. Several papers reported the use of 1,2,4-oxadiazole in a number of
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