Synthesis of .beta.-cyano-.alpha.,.beta.-unsaturated isocyanates and their reactions with hydrogen chloride

Abstract

arising from a proton bonded to nitrogen; the two hydrogens Ha and Hfl of the bridging methylene though magnetically nonequivalent would appear to experience a similar magnetic environment since the anticipated AB quartet is observed rather as a broad singlet at 4.36 with small wings at 4.50 and 4.24, the latter wing being obscured by the bridging methylene signal of the cation 7.

Palladium‐Catalyzed One‐Pot Four‐Component Synthesis of β‐Cyano‐α,β‐unsaturated Ketones Using Calcium Carbide as an Acetylene Source and Potassium Hexacyanoferrate(II) as an Eco‐Friendly Cyanide Source

“…β‐Cyano‐α,β‐unsaturated ketones contain important functional groups, such as cyano, carbonyl and alkenyl, which are significant intermediates for the synthesis of fine chemicals, such as pharmaceuticals, pesticides and perfumes . At the same time, the substances containing β‐cyano‐α,β‐unsaturated ketone moieties also have great potential application value .…”

“…[1][2][3] At the same time, the substances containing β-cyano-α,β-unsaturated ketone moieties also have great potential application value. [1][2][3] At the same time, the substances containing β-cyano-α,β-unsaturated ketone moieties also have great potential application value.…”

“…β-Cyano-α,β-unsaturated ketones contain important functional groups, such as cyano, carbonyl and alkenyl, which are significant intermediates for the synthesis of fine chemicals, such as pharmaceuticals, pesticides and perfumes. [1][2][3] At the same time, the substances containing β-cyano-α,β-unsaturated ketone moieties also have great potential application value. [4] Figure 1 shows two structures which can separately be used as a calciumchannel blocker (treating hypertension, cerebral artery occlusion [5] and Alzheimer's disease [6] ) and a new type of near-infrared dye.…”

The chemistry of .beta.-enaminonitriles as versatile reagents in heterocyclic synthesis

“…The latter reacted with dry hydrogen chloride in dioxane to give the intermediate 161 which led to the final product 5,6-disubstituted uracil 162, at 60 °C 161 was stable enough to be isolated, whereas at 100 °C only 162 was isolable (Scheme 21). 124 The reaction of phenylacetonitrile with formamide in the presence of ammonia at 180 °C gives 5-phenylpyrimidine-4-amine (166) via the intermediate 165.125 The pyrrolinones 174 were prepared from the reaction of maleic anhydride 172 and enamines 1 according to procedures described by 174…”