“…1,2 Recently we designed novel approaches to β-(1,2,3-triazol-1-yl)-α-amino acid derivatives, 3 β-(imidazol-1-yl)-α-amino acid derivatives, 4 As an extension of these investigations we describe here further functionalization of the [1,2,3]triazolo [1,5-a]pyrazine system and the synthesis of some [1,2,3]triazolo [1,5-a] [1,2,4]triazolo [5,1-c]pyrazines. We focused on the formation of 1,2,4-triazole ring fused to the N(5)=C(4)(NH 2 ) unit of the amine 1, 5 ( Figure 1), by the general synthetic method that use N,Ndimethylformamide dimethyl acetal (DMFDMA), hydroxylamine hydrochloride, and polyphosphoric acid (PPA) as the main required reagents, 7,8 thinking that this procedure could be extended to the heterocyclic system 1.…”