Synthesis of Benzofuran Derivatives and their Evaluation of Antimicrobial Activity

Abstract

2-Acetyl benzofuran (1) was synthesized by refluxing salicylaldehyde and dry chloroacetone in presence of potassium carbonate. The product formed was reacted with 2-aminobenzothiazole with catalyst p-toluene sulphonic acid to form N- [(1Z)-1-(benzofuran-2-yl)ethylidene]1,3-benzothiazol-2-amine (2). In cold condition, Staudinger reaction was carried out for compound (2) with various acid chlorides in presence of triethylamine to synthesize 4-[1-benzofuran-2-yl]-1-[1, 3-benzothiazol-2-yl]-4-methylazetidin-2-one (3a-3j). All the synthesized compounds were characterized on the basis of analytical data. The compounds were screened for their antimicrobial activities. Compound 3b, 3c and 3d exhibited moderate activity.

Benzofuranyl Esters: Synthesis, Crystal Structure Determination, Antimicrobial and Antioxidant Activities

“…Salicylaldehyde ( 1 ) (0.1 mol), chloroacetone (0.1 mol) and anhydrous potassium carbonate (30 g) were dissolved in dry acetone (150 mL) and the mixture was refluxed for about 12 h. After the mixture was cooled, the filtrate was removed under reduced pressure to obtain a yellow crude product of 1-(benzofuran-2-yl)ethanone ( 2 ) [30]. The crude product was recrystallized from petroleum ether and purity of the product were checked by using TLC plate with silica gel and acetone:benzene (1:1) solvent system.…”