Synthesis of Benzimidazolones, Benzooxazolones, 2-amino-benzothiazoles from Ethyl Cyanoformate and o-phenylene Diamines, o-aminophenols, oaminothiophenols Promoted by Lithium Bromide

Dekhane, Deepak V.; Pawar, Shivaji S.; Gupta, Sunil; Shingare, Murlidhar S.; Thore, Shivaji N.

doi:10.2174/157017811796064449

Cited by 20 publications

(13 citation statements)

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“…1,3,4‐Oxadiazoles are a very important class of heterocyclic compounds, and much attention has been paid to the chemistry and biological activities of this nucleus. Oxadiazoles are known to exhibit a wide range of biological activities, such as anticancer , antibacterial , antifungal , antidiabetic , antitubercular , and anti‐inflammatory . In addition, the triazole scaffold is an attractive moiety not only from a synthetic point of view but also in the context of biological and drug discovery applications owing to its easy formation by click chemistry.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and In Vitro Anticancer Activity of Novel 1,3,4‐Oxadiazole‐Linked 1,2,3‐Triazole/Isoxazole Hybrids

Madhavilatha

Bhattacharjee

Sabitha

et al. 2018

Journal of Heterocyclic Chem

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Section: Introductionmentioning

confidence: 99%

Synthesis and In Vitro Anticancer Activity of Novel 1,3,4‐Oxadiazole‐Linked 1,2,3‐Triazole/Isoxazole Hybrids

Madhavilatha

Bhattacharjee

Sabitha

et al. 2018

Journal of Heterocyclic Chem

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“…Very recently, it has been discovered that many aromatic bis ‐heterocyclic compounds exhibit various biological properties like antibacterial, immunostimulatory, fungicidal, tuberculostatic, and plant growth regulative properties. In view of their diverse applications and pharmacological activities, bis ‐heterocycles have received a considerable attention from synthetic chemists . Bis ‐heterocycles often act as divalent dual target interacting ligands wherein synergistic activity of two pharmacophoric groups results in improved pharmacological functions.…”

Section: Introductionmentioning

confidence: 99%

Design and Synthesis of Novel 1,2,3‐Triazole‐ and 2‐Isoxazoline‐Based Bis‐Heterocycles as Immune Potentiators

Ismail

Shafi

Hyder

et al. 2015

Archiv der Pharmazie

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A series of novel bis-heterocycles encompassing isoxazolines and triazoles were synthesized through a novel one-pot procedure that involves in situ generation of nitrile oxide and its 1,3-dipolar cycloaddition to variedly substituted acrylates. The synthesized bis-heterocycles (8a-l) were subjected to in vitro lymphocyte proliferation assays followed by in vivo studies of the more active compounds (8g and 8h) to assess their influence on various aspects of the immune system like ex vivo splenocyte proliferation (T- and B-cell proliferation), antibody production (HA titer), delayed-type hypersensitivity reaction, T-cell subtypes (CD4 and CD8), cytokine production (IL-2, IFN-γ, and IL-4), NO (macrophage) production, and toxic effects. The results from the in vitro and in vivo studies establish that the tested compounds 8g and 8h possess excellent immunopotentiating activity.

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“…Organophosphorus compounds are noteworthy for their biological activity , especially when they are associated with various heterocycles . One of the most important of these bioactive heterocycles is the pyrazole ring . On the other hand, it is known that the phosphonyl and phosphoryl groups could regulate important biological functions .…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Spectral Characterization of Some Novel Phosphonyl‐ and Phosphoryl Pyrazole Compounds

Ali

2013

Heteroatom Chemistry

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1,3-Diphenyl-1H-pyrazole-4-carbal dehyde (1) reacted with aniline, 2-substituted anilines, and P,P-dimethylphosphinic hydrazide in the presence of diethyl phosphite to give acyclic α-aminophosphonate 2, cyclic α-aminophosphonates 4-6, and α-hydrazinophosphonate 7, respectively. Also, treatment of aldehyde 1 with cyanoacetohydrazide, acetophenone, and malononitrile afforded the condensation products 8, 16, and 21, respectively, which in turn, reacted with diethyl phosphite and P,P-dimethylphosphinic hydrazide. The reaction of diethyl phosphite with the hydrazone 8 and chalcone 16 yielded the novel phosphorus heterocycles 13 and 18, respectively, while its reaction with the dicyanoarylidene 21 produced the dicyanopyrazolyl phosphonate 22. On the other hand, treatment of the hydrazone 8 with P,P-dimethylphosphinic hydrazide gave the unexpected P,P-dimethylphosphinic hydrazone 15, which reacted with diethyl phosphite forming α-hydrazinophosphonate 7. Furthermore, the interesting N-phosphoryl pyrazoles 20 and 24 were resulted in good yield via cycloaddition of P,P-dimethylphosphinic hydrazide to the chalcone 16 and dicyanoarylidene 21, respectively. Structures of all newly synthesized compounds were confirmed by considering the data of IR spectroscopy, MS, and

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Synthesis of Benzimidazolones, Benzooxazolones, 2-amino-benzothiazoles from Ethyl Cyanoformate and o-phenylene Diamines, o-aminophenols, oaminothiophenols Promoted by Lithium Bromide

Cited by 20 publications

References 0 publications

Synthesis and In Vitro Anticancer Activity of Novel 1,3,4‐Oxadiazole‐Linked 1,2,3‐Triazole/Isoxazole Hybrids

Synthesis and In Vitro Anticancer Activity of Novel 1,3,4‐Oxadiazole‐Linked 1,2,3‐Triazole/Isoxazole Hybrids

Design and Synthesis of Novel 1,2,3‐Triazole‐ and 2‐Isoxazoline‐Based Bis‐Heterocycles as Immune Potentiators

Synthesis and Spectral Characterization of Some Novel Phosphonyl‐ and Phosphoryl Pyrazole Compounds

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