Synthesis of basic and applied research is the basis of obtaining high-quality findings and translating them into clinical practice

Каприн, А. Д.; Галкин, В Н; Zhavoronkov, L P; Иванов, В.К.; Иванов, С. А.; Romanko, Yu. S.

doi:10.21870/0131-3878-2017-26-2-26-40

Cited by 46 publications

(5 citation statements)

References 3 publications

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“…(2017 г.) на основе целевого анализа комплекса исследований, отмечена значимость методов лучевой диагностики (в т. ч. и МРТ) в установлении первичного и метастатического поражения различных органов опухолью и динамического наблюдения за их состоянием при этом [22].…”

Section: Discussionunclassified

The informative value of magnetic resonance imaging with the application of the protocol of diffusion-weighted images in the assessment of the endometrium when multiple neoplasias

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Safonova

Захарова

et al. 2020

Issled. prakt. med. (Print)

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Purpose of the study. To study the diagnostic informativeness of magnetic resonance imaging (MRI) with the assessment of diffusion- weighted images and the measured diffusion coefficient in the diagnosis of endometrial tumor lesions in polyineoplasias.Materials and methods. The article presents the results of a study of patients with synchronous and metachronous polyneoplasias who were in the AU "Republican clinical oncological dispensary" of the Ministry of health of the Chuvash Republic from 2014 to 2018. All were performed magnetic resonance imaging on Excelart Vantage Atlas (Toshiba, Japan, 1.5 T), ultrasound (Aplio, Xario and Nemio, Toshiba, Japan; Sono Scape, China), x-ray computed tomography on Light Speed VEX Plus and Light Speed RT 16 (GE, USA). All MRI results were compared with morphological data obtained afterhistomorphological examination of the postoperative material. The differences were considered significant at values p≤0.05.Results. 80 cases of endometrial tumor lesions in polyineoplasias (N1a) were detected, which was 44.7% of all cases of the main group (N1; n=179), of which metachronous polyineoplasias were found in 56 (70.0%), synchronous — in 11 (13.7%), combined — in 13 (16.3%) patients. The informative value of MRI in the diagnosis of malignant neoplasms with lesions of the endometrium when multiple neoplasias were: sensitivity of 91.3%, specificity — 82,4%, accuracy was 89.7% (p<0.001).Conclusions. Magnetic resonance imaging using the diffusion- weighted image Protocol with an assessment of the measured diffusion coefficient has shown high information both in the diagnosis of primary endometrial tumor lesions in primary multiple malignancies, and in establishing the stage of the tumor process and in the diagnosis of subsequent malignancies.

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Section: Discussionunclassified

The informative value of magnetic resonance imaging with the application of the protocol of diffusion-weighted images in the assessment of the endometrium when multiple neoplasias

Николаевна

Safonova

Захарова

et al. 2020

Issled. prakt. med. (Print)

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“…В работе отражены результаты исследования, выполненного в ФГБУ «НМИЦ радиологии» Минздрава России, который много лет успешно внедряет в клиническую практику собственные экспериментальные методики в области ядерной медицины, лучевой терапии онкологических и неонкологических заболеваний, управления радиочувствительностью опухолевых и нормальных тканей на основе новых знаний о механизмах канцерогенеза [26].…”

Section: заключениеunclassified

Synergistic ideas in oncology: prospects for practical implementation

Евстратова

Петин

2020

Issled. prakt. med. (Print)

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The review is devoted to the analysis of the problem of synergistic ideas application in oncology after simultaneous combined application of agents. An example of the determination and quantification of the synergistic enhancement ratio is presented. It is emphasized that independent addition is determined by product of probabilities of the effects induced by each agent applied separately. Elevated temperatures synergistically enhance the lethal effect of ionizing radiation and chemical compounds used in the treatment of cancer. Analyzing the dependence of the synergistic effect on the acting temperature after its simultaneous application with ionizing radiation or cisplatin, the existence of an optimal temperature ensuring the greatest synergistic interaction was shown for cultured mammalian and yeast cells. The universal regularities of the manifestation of synergism, independent on the agents, biological objects and tests used, are noted. The greatest synergy is observed with the simultaneous application of agents. The synergism recorded as a result of the combined effects of two factors is observed only with a certain ratio of the effects induced by each agent. Synergism depends on the intensity of the factors used — the current temperature, the dose rate of ionizing radiation or the concentration of chemical agents. These universal patterns have been demonstrated for proand eukaryotic cells, including oncological origin. The existence of universal patterns of synergism indicates the need to develop a new paradigm and theoretical model of synergism, which should take into account the identified patterns. An original biophysical concept of synergistic interaction is proposed. Concrete results are presented that demonstrate the possible ways of using the ideas of synergism in oncology by achieving the greatest synergistic enhancement ratio for the combined effects of various physical and chemical agents. It is concluded that the knowledge and the application of the ideas and general patterns of synergy described in this paper can be useful for specialists using the simultaneous action of various agents to optimize combined treatment methods in modern oncology.

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“…В работе отражены результаты исследования, выполненного в МРНЦ им. А. Ф. Цыба -филиале НМИЦ радиологии, который много лет успешно внедряет в клиническую практику собственные экспериментальные методики в области ядерной медицины, лучевой терапии онкологических и неонкологических заболеваний, управления радиочувствительностью опухолевых и нормальных тканей на основе новых знаний о механизмах канцерогенеза [38].…”

Section: заключениеunclassified

Study of association between molecular marker expression on tumor and immunocompetent cells and sensitivity to adjuvant and neoadjuvant therapy of bladder cancer

et al. 2019

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Use of immunotherapy in treatment of muscle-invasive bladder cancer remains the most promising method in case of impossibility of chemotherapy with cisplatin or progression during cisplatin treatment. This approach is the method of choice and can prolong patient’s life. In particular, use of checkpoint inhibitors allows to obtain effective treatment of bladder cancer. However, to prescribe immunotherapeutic medication, patient must have point of application for these drugs. Individualized approach will allow to increase treatment effectiveness and disease prognosis while maximally improving the quality of life.

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Synthesis of basic and applied research is the basis of obtaining high-quality findings and translating them into clinical practice

Cited by 46 publications

References 3 publications

The informative value of magnetic resonance imaging with the application of the protocol of diffusion-weighted images in the assessment of the endometrium when multiple neoplasias

The informative value of magnetic resonance imaging with the application of the protocol of diffusion-weighted images in the assessment of the endometrium when multiple neoplasias

Synergistic ideas in oncology: prospects for practical implementation

Study of association between molecular marker expression on tumor and immunocompetent cells and sensitivity to adjuvant and neoadjuvant therapy of bladder cancer

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