Synthesis of arylidenepyruvic amide derivatives via Ugi-four component condensation

Soleymanifard, Bita; Heravi, Majid M.; Shiri, Morteza; Zolfigol, Mohammad Ali; Rafiee, Mohammad; Kruger, Hendrik G.; Naicker, Tricia; Rasekhmanesh, Farzaneh

doi:10.1016/j.tetlet.2012.04.126

Cited by 26 publications

(6 citation statements)

References 13 publications

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“…We have a continued interest to develop efficient approaches to explore valuable compounds via Ugi 4-CC reactions [6,21,22]. Herein we report the highly selective synthesis of indole-based heterocycles from the Ugi adducts.…”

Section: Resultsmentioning

confidence: 99%

Base-catalyzed cyclization of Ugi-adducts to substituted indolyl based γ-lactams

et al. 2014

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Section: Resultsmentioning

confidence: 99%

Base-catalyzed cyclization of Ugi-adducts to substituted indolyl based γ-lactams

et al. 2014

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“…Stepwise regression is the sequence of multiple linear regressions in a step-by-step procedure. One trait is added to the regression model at each step to reduce the error sum of squares (Leilah & Al-Khateeb 2005;Soleymanifard et al 2012). Draper and Smith (1966) used this procedure to determine the variable that explain the majority of the total yield variability.…”

Section: Statistical Analysis For Genotypic Screening Under Saline Conditionsmentioning

confidence: 99%

Breeding for salt tolerance in wheat: The contribution of carbon isotopic signatures

Chamekh¹,

Zouari²,

Jallouli³

et al. 2022

CZECH J GENET PLANT

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Use of low-quality water for supplemental irrigation is expected to become soon a common practice in the Mediterranean area, where durum wheat is the main cultivated cereal. Breeding for salt stress tolerance may contribute to the improvement of wheat resilience to irrigation with brackish water. Various traits can be considered as indicators of salt stress tolerance, which include agronomical and physiological criteria. However, the complexity of salinity tolerance mechanisms, the G × E interaction and the lack of correlation between controlled and open field conditions causes uncertainty in the selection process. The present review highlights the main advantages and limitations of different agronomical and physiological traits used in screening for salt stress tolerance in wheat. Special focus is given to carbon and nitrogen isotope discrimination, that remains a bottleneck in breeding for salt stress tolerance. The use of different statistical tools to analyse data related to salt stress tolerance is also discussed in this review.

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“…We are interested in heterocyclic chemistry [36][37][38][39][40][41][42][43][44][45] and reported the synthesis of several heterocyclic systems via MCRs [46][47][48][49][50][51][52][53]. We have also recently reported the synthesis of various heterocyclic systems via the appropriate post-Ugi-adducts reaction [54][55][56][57][58]. Herein, we wish to report a transition metal-free catalyzed and highly region-and diastereoselective approach towards the synthesis of oxo-1,2,3,4tetrahydropyrazino[1,2-a]indoles.…”

Section: Introductionmentioning

confidence: 99%

Highly regio- and diastereoselective synthesis of oxo-1,2,3,4-tetrahydropyrazino[1,2-a]indoles, based on a post-Ugi condensation: joint experimental and computational study

et al. 2019

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A novel series of oxo-1,2,3,4-tetrahydropyrazino[1,2-a]indoles were synthesized via a two-step pathway. In the first step, Ugi-four-component condensation of 2-formylindole, amines, (E)-4-alkoxy-4-oxobut-2-enoic acids, and isocyanides gave the corresponding Ugi-adducts. This adduct underwent intramolecular hydroamination in the presence of K 2 CO 3 in CH 3 CN at room temperature to afford diastereoselective synthesis of a range of oxo-1,2,3,4-tetrahydropyrazino[1,2-a]indoles. A comparison of experimentally observed CD and UV-visible spectra with the theoretical DFT calculated ECD spectra was used to predict the major diastereomer.

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Synthesis of arylidenepyruvic amide derivatives via Ugi-four component condensation

Cited by 26 publications

References 13 publications

Base-catalyzed cyclization of Ugi-adducts to substituted indolyl based γ-lactams

Base-catalyzed cyclization of Ugi-adducts to substituted indolyl based γ-lactams

Breeding for salt tolerance in wheat: The contribution of carbon isotopic signatures

Highly regio- and diastereoselective synthesis of oxo-1,2,3,4-tetrahydropyrazino[1,2-a]indoles, based on a post-Ugi condensation: joint experimental and computational study

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