Synthesis of aromatic natural product frameworks using enyne metathesis

Recent Advances on Transition-Metal-Catalyzed Allenamides Cyclization

“…在 Pd 催化联烯胺环化的研究进展中, Grigg 课题 组 [13] 在 1996 年报道了一例锡烷基化-碳钯化串联反应 构建含氮、氧杂环的反应(Scheme 13). 转化经历联烯胺 α 位碳原子区域选择性环化, 得到中环(5～7)和大环 [23] 、自由基反应 [24] 、硅烷活化 [25] 、环丙烷化 [26] 、环 丙烷差向异构化 [27] 、氧化 [28] 、氢化乙烯化 [29] 、[4＋2]环 加成 [30] 、[3＋2]环加成 [31] 、[2＋2＋2]环加成 [32] 2012 年, Hsung 课题组 [43] Cat. (2 mol%) AgSgF 6 (2 mol%)…”

Transition‐Metal‐Mediated or ‐Catalyzed Syntheses of Steroids and Steroid‐Like Compounds

“…[50] The enyne metathesis was first outlined by Pérez-Castills et al, who showed that the various 1-ethynyl-2-(ω-alkenyl)-benzenes 56 (Scheme 21) could easily be converted into the vinyl-3,4-dihydronaphthalenes (and heteroanalogues) 57 in the presence of catalytic amounts of G I catalyst. [57] This approach was later extended by Hanzawa et al…”

Unique Metal‐Diyne, ‐Enyne, and ‐Enediyne Complexes: Part of the Remarkably Diverse World of Metal‐Alkyne Chemistry

“…As an extension of their previous contribution, in 1996 Mori and co-workers (428a) reported the first application of a ring-closing enyne metathesis reaction in a total synthesis, namely, that of the tricyclic alkaloid (À)-stemoamide in 9% overall yield (Scheme 44). Within this theme, natural products have more recently been constructed using Grubbs metathesis of aromatic enynes to produce 1,3-dienes that subsequently undergo a Diels-Alder reaction to give the desired product (440,441).…”