Synthesis of antimicrobial polymer composition and in vitro drugs release study

Tudorachi, Niță

doi:10.1515/epoly.2008.8.1.1504

Cited by 3 publications

(2 citation statements)

References 19 publications

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“…The bands are located at 2921 and 2863 cm −1 , whose assignments correspond to the CH 3 and CH 2 groups that are part of both the polymer and the ASA molecule, thereby confirming the interaction between them. These results are similar to those reported by Nita [19] and Yang and Wang [20].…”

Section: Resultssupporting

confidence: 92%

Acetylsalicylic Acid (ASA) on Hydroxyethylcellulose/Polyacrylamide Gel (HEC/PAAm) as a Proposal for a Dermatological Compress: Mathematical Modeling of ASA Release Kinetics

Castillo-Miranda

Castro-Guerrero

Velasco-Ocejo

et al. 2019

International Journal of Polymer Science

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Currently, acne in adolescents and adults is caused by an infection in follicles caused by hormonal changes, stress, water pollution, air, and earth; the last one comes into contact with the skin through the hands of patients. This project presents the incorporation of acetylsalicylic acid (ASA) to the hydroxyethylcellulose/polyacrylamide gel (HEC/PAAm) in the synthesis of gel or by its swelling.The results show us that the incorporation of ASA is possible by both methods; first, the incorporation by synthesis of degradation of the gel is more visible. The infrared spectroscopic analysis shows the functional groups of gel and ASA, 2921 and 2863 cm −1 , whose assignments correspond to CH 3 and CH 2 groups, which are part of both the polymer and the ASA molecule, which confirms the interaction between the two groups. The microscopy photographs (SEM) show on the surface the drug in irregular whitish orthorhombic forms due to swelling; arborescent structures are observed in the case of the incorporation of the ASA drug by synthesis. Swelling kinetics has a Fickian form. The Higuchi model conforms to the release of ASA because the level of confidence is 90%. This gel was allowed to release 0.35 mg/hour, thus allowing the patient to have a continuous form of the release, in the affected area in a short period of time.

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Section: Resultssupporting

confidence: 92%

Acetylsalicylic Acid (ASA) on Hydroxyethylcellulose/Polyacrylamide Gel (HEC/PAAm) as a Proposal for a Dermatological Compress: Mathematical Modeling of ASA Release Kinetics

Castillo-Miranda

Castro-Guerrero

Velasco-Ocejo

et al. 2019

International Journal of Polymer Science

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“…Customer products like dietary supplements clothing, antibacterial sprays, respirators, detergent already utilize the silver nanoparticles in one form or another. These forms of nanomaterials are: metallic silver nanoparticles (8), AgCl particles (9), Ag impregnated zeolite powders (10), dendrimer silver compounds and structures (11), polymer AgNPs composites (12)(13), silvertitanium dioxide compounds nanopowders (14). The antibacterial studies can be conducted through a variety of methods such as Kirby-Bauer and Stokes method (Clinical and Laboratory Standards Institute, 2008), Minimum Inhibitory Concentration (MIC), Etest method.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Antibacterial Activity of Silver Nanoparticles: Systematic Review

Thakur

2024

IJSREM

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Silver is exploited for the benefit of mankind from past centuries. Silver has been proved to be much more powerful when compared to other metallic nanoparticles, not only bactericidal properties but it is also effective against eukaryotic microorganisms and viruses. Creation of Ag Nanoparticles has increased the silver efficacy many folds due to their physical and chemical properties, especially the surface area to volume ratio is most important imparting the antibacterial activity over various microorganisms. To lessen bacterial infections in incurable wounds nanocrystalline silver dressings, creams, gels are formulated. However, several problems are associated with the use. Silver nanoparticle toxicity is a major threat associated with their use and the inhibition of beneficiary microorganisms due to lack of specificity of silver nanoparticles is environmentalist’s concern. To reduce the threats associated, there should be a careful assessment of the silver nanoparticles release into the environment and should be regulated. It has to be noted that novel methods to produce silver nanoparticles which reduce the toxicity and other associated threats has to be developed in the future to exploit the vast capabilities of the silver nanoparticles for the benefit of mankind. As technology advancement is always in demand with changing environmental conditions, the present review will focus on the synthesis and antibacterial properties of silver nanoparticles along with its environmental impact. Key Words: Silver nanoparticles ∙ Antibacterial Activity ∙ Microorganisms ∙ Environmental Impact

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