Synthesis of amphiphilic poly(tetraethylene glycol succinate) and the thermosensitivity of its aggregation in water

Abstract

Amphiphilic biodegradable polyester, poly(tetraethylene glycol succinate) (PTEGSuc), was synthesized via melt polycondensation of tetraethylene glycol and succinic acid on catalysis of p-toluenesulfonic acid. It was observed that PTEGSuc could self-assemble into micelles in water. In addition, thermosensitivity of PTEGSuc aggregation in water was first found in the experiment, and the critical aggregation temperatures could be controlled by solution concentration. Transmission electron microscopy was used to investigate the micellar morphologies of PTEGSuc in different solvents. It was found that particle shape is almost round although the micellar morphology is different depending on the solvent used. Based on the perfect properties, especially in micelle formation and thermosensitivity, PTEGSuc is promising in biomedical field as carrier of drug delivery system, scaffold of tissue engineering, and other medical devices.

Preparation and tunable temperature sensitivity of biodegradable polyurethane nanoassemblies from diisocyanate and poly(ethylene glycol)

“…16 Recently, a kind of biodegradable alternative polyester (poly(tetraethylene glycol succinate)) was developed in our group, exhibiting reversible temperature sensitivity. 17 Inspired by this promising result, we synthesized a series of alternative poly(urethane)s and their temperature sensitivities were evaluated.…”

Consequences of Dispersity on the Self-Assembly of ABA-Type Amphiphilic Block Co-Oligomers

“… 24 , 25 oTEGSuc block was chosen as a biodegradable substitute to PEG, to generate fully biodegradable ABCOs. 26 Discrete chains of oTEGSuc can be synthesized following the iterative synthetic approach presented in Scheme 1 . The l -lactic acid 16-mer was selected as the hydrophobic core either as a discrete 16-mer of exact molecular weight (LLA 16 ) or as a disperse one (LLA ∼16 ) with Đ = 1.20.…”

“… 2 For an invariant ratio, MeOoEG was replaced with a TEGSuc block of comparable molar mass. Possibly, the more hydrophobic nature of the TEGSuc block 26 changes this balance, leading to the formation of vesicles or bilayers.…”

Synthesis of Schiff Base Unsaturated Oligomeric Polyester for Determination of Trace Lead

“…The study of Table ( 1) indicate that the degree of polymerization, mean molecular weight and acid value were determined by the end group analysis and calculation of the mean M. wt. were in the range 4872-7773 by the standard method [35][36] and degree of polymerization range 9-16 unit which give copolymer with medium molecular weight. All polyesters are yellowish viscous.…”