Synthesis of Alpha-Tricalcium Phosphate by Wet Reaction and Evaluation of Mechanical Properties

Abstract

Calcium phosphate cements have bioactivity and osteoconductivity and can be molded and replace portions of bone tissue. The aim of this work was to study the obtainment of α-tricalcium phosphate, the main phase of calcium phosphate cement, by wet reaction from calcium nitrate and phosphoric acid. There are no reports about α-tricalcium phosphate obtained by this method. Two routes of chemical precipitation were evaluated and the use of two calcinations temperatures to obtain the phase of cement. The influence of calcination temperature on the mechanical properties of cement was evaluated. Cement samples were characterized by particle size analysis, X-ray diffraction, mechanical strength and scanning electron microscopy. The results demonstrate the strong influence of synthesis route on the crystalline phases of cement and the influence of concentration of reactants on the product of the reaction, as well as, on the mechanical properties of cement.

Calcium phosphate cements based on alpha-tricalcium phosphate obtained by wet method: Synthesis and milling effects

“…However, the use of higher temperature calcination (1500°C) apparently resulted in obtaining alpha-TCP with a higher purity. This result corroborates with the results of previous work, demonstrating the reproducibility of the method [25]. From Fig.…”

“…Previous studies was conducted using different reagents concentration and different calcination temperature [25,26]. Therefore, this work aims to complement previous work in order to consolidate the best methodology to obtain alpha-tricalcium phosphate with high purity by wet precipitation process.…”

Influence of polyacrylic acid (PAA)/Na2HPO4 mixture on biphasic calcium phosphate cement: Enhancing strength and cell viability

“…The α-TCP powder was synthesized by wet chemical reaction method, followed by. 24,25 Briefly, 0.5 M calcium nitrate (Ca(NO 3 ) 2 •4H 2 O) was mixed with 0.5 M phosphoric acid (H 3 PO 4 ). The solution was incubated at 90°C for 24 h, then dried at 120°C.…”

Surface and mechanical properties of adhesives with calcium phosphates challenged to different storage media

“…The group containing HAp showed larger cavities with irregular limits distributed over a slightly smooth surface. It is possible that these cavities were created due to the release of HAp agglomerates because low values of surface area were found for HAp previously synthesized by the same method 24 . Nanoparticles are prone to agglomeration due to their high surface energy.…”

“…These reagents were purchased from Aldrich Chemical, St Louis, MO, USA. Three CaP were previously synthesized, and they were added in this base resin at 2 wt.%: α-TCP (G α-TCP , 6.03 µm) 22 , OCP (G OCP , 4.94 nm) 23 and HAp (G HAp , 26.7 nm) 24 . A group without CaP was used as control (G Ctrl ), totaling four groups.…”